Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome

• Published in: iScience Vol. 9; pp. 161 - 174
• Main Authors: Aoyama, Kazumasa, Oshima, Motohiko, Koide, Shuhei, Suzuki, Emi, Mochizuki-Kashio, Makiko, Kato, Yuko, Tara, Shiro, Shinoda, Daisuke, Hiura, Nobuhiro, Nakajima-Takagi, Yaeko, Sashida, Goro, Iwama, Atsushi
• Format: Journal Article
• Language: English
• Published: United States Elsevier 30.11.2018
• Subjects: Biological Sciences; Genetics; Immunology; Molecular Biology; Developmental Biology; Cell Biology

Polycomb repressive complex (PRC) 2 represses transcription through histone H3K27 trimethylation (H3K27me3). We previously reported that the hematopoietic-cell-specific deletion of Ezh2, encoding a PRC2 enzyme, induced myelodysplastic syndrome (MDS) in mice, whereas the concurrent Ezh1 deletion depl...