Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases

Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium with its barrier function is in charge of a tightly controlled antigen trafficking from the intestinal lumen to the submucosa. This trafficking dictates the delicate balance between tolerance and immune resp...

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Bibliographic Details
Published inTissue barriers Vol. 4; no. 4; p. e1251384
Main Authors Sturgeon, Craig, Fasano, Alessio
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.10.2016
Subjects
Animals
autoimmune disease
Autoimmune Diseases - blood
Autoimmune Diseases - etiology
barrier function
Cholera Toxin - blood
Cholera Toxin - toxicity
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Humans
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - etiology
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
intestinal permeability
Reviews
tight junctions
Tight Junctions - drug effects
Tight Junctions - metabolism
zonulin
intestinal permeability
zonulin
tight junctions
autoimmune disease
barrier function
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Abstract Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium with its barrier function is in charge of a tightly controlled antigen trafficking from the intestinal lumen to the submucosa. This trafficking dictates the delicate balance between tolerance and immune response causing inflammation. Loss of barrier function secondary to upregulation of zonulin, the only known physiological modulator of intercellular tight junctions, leads to uncontrolled influx of dietary and microbial antigens. Additional insights on zonulin mechanism of action and the recent appreciation of the role that altered intestinal permeability can play in the development and progression of chronic inflammatory disorders has increased interest of both basic scientists and clinicians on the potential role of zonulin in the pathogenesis of these diseases. This review focuses on the recent research implicating zonulin as a master regulator of intestinal permeability linked to the development of several chronic inflammatory disorders.
AbstractList Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium with its barrier function is in charge of a tightly controlled antigen trafficking from the intestinal lumen to the submucosa. This trafficking dictates the delicate balance between tolerance and immune response causing inflammation. Loss of barrier function secondary to upregulation of zonulin, the only known physiological modulator of intercellular tight junctions, leads to uncontrolled influx of dietary and microbial antigens. Additional insights on zonulin mechanism of action and the recent appreciation of the role that altered intestinal permeability can play in the development and progression of chronic inflammatory disorders has increased interest of both basic scientists and clinicians on the potential role of zonulin in the pathogenesis of these diseases. This review focuses on the recent research implicating zonulin as a master regulator of intestinal permeability linked to the development of several chronic inflammatory disorders.
Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium with its barrier function is in charge of a tightly controlled antigen trafficking from the intestinal lumen to the submucosa. This trafficking dictates the delicate balance between tolerance and immune response causing inflammation. Loss of barrier function secondary to upregulation of zonulin, the only known physiological modulator of intercellular tight junctions, leads to uncontrolled influx of dietary and microbial antigens. Additional insights on zonulin mechanism of action and the recent appreciation of the role that altered intestinal permeability can play in the development and progression of chronic inflammatory disorders has increased interest of both basic scientists and clinicians on the potential role of zonulin in the pathogenesis of these diseases. This review focuses on the recent research implicating zonulin as a master regulator of intestinal permeability linked to the development of several chronic inflammatory disorders.
Author Fasano, Alessio
Sturgeon, Craig
Author_xml – sequence: 1
  givenname: Craig
  surname: Sturgeon
  fullname: Sturgeon, Craig
  organization: Graduate Program in Life Sciences, University of Maryland School of Medicine
– sequence: 2
  givenname: Alessio
  surname: Fasano
  fullname: Fasano, Alessio
  email: afasano@mgh.harvard.edu
  organization: European Biomedical Research Institute of Salerno (EBRIS)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28123927$$D View this record in MEDLINE/PubMed
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SSID ssj0000826074
Score 2.5229774
SecondaryResourceType review_article
Snippet Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium with its barrier function is in charge of a tightly controlled...
SourceID pubmedcentral
pubmed
crossref
informaworld
SourceType Open Access Repository
Index Database
Enrichment Source
Publisher
StartPage e1251384
SubjectTerms Animals
autoimmune disease
Autoimmune Diseases - blood
Autoimmune Diseases - etiology
barrier function
Cholera Toxin - blood
Cholera Toxin - toxicity
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Humans
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - etiology
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
intestinal permeability
Reviews
tight junctions
Tight Junctions - drug effects
Tight Junctions - metabolism
zonulin
Title Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases
URI https://www.tandfonline.com/doi/abs/10.1080/21688370.2016.1251384
https://www.ncbi.nlm.nih.gov/pubmed/28123927
https://pubmed.ncbi.nlm.nih.gov/PMC5214347
Volume 4
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