Effect of Phenol Inducing the Antioxidant Responsive Element on Drosophila Melanogaster Lifespan

• Published in: Bulletin of experimental biology and medicine Vol. 150; no. 1; pp. 65 - 67
• Main Authors: Menshchikova, E. B., Zenkov, N. K., Weisman, N. Ya, Kandalintseva, N. V., Prosenko, A. E.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.12.2010; Springer; Springer Nature B.V
• Subjects: Animals; Antioxidants; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Drosophila; Drosophila melanogaster - drug effects; Drosophila melanogaster - genetics; Female; Genetics; Genotype; Internal Medicine; Laboratory Medicine; Longevity - drug effects; Longevity - genetics; Male; Molecular Structure; Pathology; Phenol - chemical synthesis; Phenol - chemistry; Phenol - pharmacology; Phenols; Sex Factors; Telomerase; Drosophila melanogaster; phenol antioxidant; lifespan
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-010-1070-5

The effect of hydrophilic synthetic antioxidant TC-13 (3-(3’-tert-butyl-4’-hydroxyphenyl) propylthiosulfonate sodium) inducing the antioxidant-responsive element on the lifespan of Drosophila melanogaster was studied. Addition of 1% TC-13 to diets prolonged the lifespan of long-lived D. melanogaster Canton S strain females and males, but not of short-lived Oregon R insects and reduced the mean lifespan of D. melanogaster males of the lgl558OR/Cy strain containing a recessive lethal mutation of tumor suppressor in the heterozygotic state. The geroprotective effects of TC-13 synthetic phenol antioxidant depended on D. melanogaster genotype and gender.