Tight junction modulation of the blood brain barrier: CNS delivery of small molecules

• Published in: Tissue barriers Vol. 4; no. 1; p. e1138017
• Main Authors: Greene, Chris, Campbell, Matthew
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02.01.2016
• Subjects: Animals; Blood-Brain Barrier - cytology; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Capillary Permeability; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Humans; Review; Tight Junction Proteins - metabolism; Tight Junctions - drug effects; Tight Junctions - metabolism

The blood brain barrier (BBB) represents a major obstacle for targeted drug delivery to the brain for the treatment of central nervous system (CNS) disorders. Significant advances in barrier research over the past decade has led to the discovery of an increasing number of structural and regulatory p...