Epigenetic changes and assisted reproductive technologies
Children conceived by Assisted Reproductive Technologies (ART) are at moderately increased risk for a number of undesirable outcomes, including low birth weight. Whether the additional risk is associated with specific procedures used in ART or biological factors that are intrinsic to infertility has...
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| Published in | Epigenetics Vol. 15; no. 1-2; pp. 12 - 25 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Taylor & Francis
01.02.2020
Taylor & Francis Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1559-2294 1559-2308 1559-2308 |
| DOI | 10.1080/15592294.2019.1646572 |
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| Abstract | Children conceived by Assisted Reproductive Technologies (ART) are at moderately increased risk for a number of undesirable outcomes, including low birth weight. Whether the additional risk is associated with specific procedures used in ART or biological factors that are intrinsic to infertility has been the subject of much debate, as has the mechanism by which ART or infertility might influence this risk. The potential effect of ART clinical and laboratory procedures on the gamete and embryo epigenomes heads the list of mechanistic candidates that might explain the association between ART and undesirable clinical outcomes. The reason for this focus is that the developmental time points at which ART clinical and laboratory procedures are implemented are precisely the time points at which large-scale reorganization of the epigenome takes place during normal development. In this manuscript, we review the many human studies comparing the epigenomes of ART children with children conceived in vivo, as well as assess the potential of individual ART clinical and laboratory procedures to alter the epigenome. |
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| AbstractList | Children conceived by Assisted Reproductive Technologies (ART) are at moderately increased risk for a number of undesirable outcomes, including low birth weight. Whether the additional risk is associated with specific procedures used in ART or biological factors that are intrinsic to infertility has been the subject of much debate, as has the mechanism by which ART or infertility might influence this risk. The potential effect of ART clinical and laboratory procedures on the gamete and embryo epigenomes heads the list of mechanistic candidates that might explain the association between ART and undesirable clinical outcomes. The reason for this focus is that the developmental time points at which ART clinical and laboratory procedures are implemented are precisely the time points at which large-scale reorganization of the epigenome takes place during normal development. In this manuscript, we review the many human studies comparing the epigenomes of ART children with children conceived in vivo, as well as assess the potential of individual ART clinical and laboratory procedures to alter the epigenome. Children conceived by Assisted Reproductive Technologies (ART) are at moderately increased risk for a number of undesirable outcomes, including low birth weight. Whether the additional risk is associated with specific procedures used in ART or biological factors that are intrinsic to infertility has been the subject of much debate, as has the mechanism by which ART or infertility might influence this risk. The potential effect of ART clinical and laboratory procedures on the gamete and embryo epigenomes heads the list of mechanistic candidates that might explain the association between ART and undesirable clinical outcomes. The reason for this focus is that the developmental time points at which ART clinical and laboratory procedures are implemented are precisely the time points at which large-scale reorganization of the epigenome takes place during normal development. In this manuscript, we review the many human studies comparing the epigenomes of ART children with children conceived in vivo, as well as assess the potential of individual ART clinical and laboratory procedures to alter the epigenome.Children conceived by Assisted Reproductive Technologies (ART) are at moderately increased risk for a number of undesirable outcomes, including low birth weight. Whether the additional risk is associated with specific procedures used in ART or biological factors that are intrinsic to infertility has been the subject of much debate, as has the mechanism by which ART or infertility might influence this risk. The potential effect of ART clinical and laboratory procedures on the gamete and embryo epigenomes heads the list of mechanistic candidates that might explain the association between ART and undesirable clinical outcomes. The reason for this focus is that the developmental time points at which ART clinical and laboratory procedures are implemented are precisely the time points at which large-scale reorganization of the epigenome takes place during normal development. In this manuscript, we review the many human studies comparing the epigenomes of ART children with children conceived in vivo, as well as assess the potential of individual ART clinical and laboratory procedures to alter the epigenome. |
| Author | Mani, Sneha Ghosh, Jayashri Sapienza, Carmen Coutifaris, Christos Mainigi, Monica |
| Author_xml | – sequence: 1 givenname: Sneha orcidid: 0000-0003-0384-8907 surname: Mani fullname: Mani, Sneha organization: Department of Obstetrics and Gynecology, University of Pennsylvania – sequence: 2 givenname: Jayashri orcidid: 0000-0002-4929-5829 surname: Ghosh fullname: Ghosh, Jayashri organization: Fels Institute for Cancer Research and Molecular Biology, Temple University – sequence: 3 givenname: Christos surname: Coutifaris fullname: Coutifaris, Christos organization: Department of Obstetrics and Gynecology, University of Pennsylvania – sequence: 4 givenname: Carmen surname: Sapienza fullname: Sapienza, Carmen organization: Fels Institute for Cancer Research and Molecular Biology, Temple University – sequence: 5 givenname: Monica orcidid: 0000-0003-3306-4791 surname: Mainigi fullname: Mainigi, Monica email: mainigim@uphs.upenn.edu organization: Department of Obstetrics and Gynecology, University of Pennsylvania |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31328632$$D View this record in MEDLINE/PubMed |
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| Title | Epigenetic changes and assisted reproductive technologies |
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