Tortoises, hares, and vaccines: A cautionary note for SARS-CoV-2 vaccine development

• Published in: Vaccine Vol. 38; no. 27; pp. 4219 - 4220
• Main Author: Poland, Gregory A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 02.06.2020; Elsevier Limited
• Subjects: Adjuvants; Allergy and Immunology; Animal models; Antigens; Betacoronavirus - immunology; Clinical Trials as Topic; Coronavirus Infections - immunology; Coronavirus Infections - prevention & control; Coronaviruses; COVID-19; COVID-19 Vaccines; Drug Approval; Drug Development; Emergency response; First responders; Health risks; Humans; Immunogenicity; Mutation; Pandemics; Risk; RNA viruses; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Time Factors; Vaccine development; Vaccines; Viral diseases; Viral Vaccines - immunology; United States > US

[...]RNA viruses accumulate mutations that can sometimes circumvent vaccine-induced immunity. [...]issues of broad immunogenicity exist. Who should be included—perhaps healthcare providers and first responders who share the highest risk of infection as a starting point? –What, if any, animal models...