Dually fibronectin/CD44-mediated nanoparticles targeted disrupt the Golgi apparatus and inhibit the hedgehog signaling in activated hepatic stellate cells to alleviate liver fibrosis

• Published in: Biomaterials Vol. 301; p. 122232
• Main Authors: Li, Yanping, Zhang, Ting, Zhang, Jinhang, Liu, Qinhui, Jia, Qingyi, Chen, Wenfei, Tang, Qin, Xiong, Yimin, Xia, Yan, Xu, Ying, Mo, Li, Huang, Yuan, He, Jinhan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2023; Elsevier BV
• Subjects: Animals; CD44; Fibronectin; Fibronectins; Golgi Apparatus; Hedgehog Proteins; Hedgehog signaling pathway; Hepatic Stellate Cells; Ligands; Liver; Liver Cirrhosis; Liver fibrosis; Mice; Nanoparticles; Hepatic stellate cells; Hedgehog signaling pathway; Liver fibrosis; Fibronectin; CD44; Golgi apparatus

Liver fibrosis is featured by activation of hepatic stellate cells (HSCs) and excessive accumulation of extracellular matrix (ECM). The Golgi apparatus in HSCs plays a vital role in synthesis and secretion of ECM proteins, while its targeted disruption in activated HSCs could be considered as a prom...