Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors

• Published in: Journal of allergy and clinical immunology Vol. 142; no. 2; pp. 695 - 698.e4
• Main Authors: Doan, Ton C., Jeong, Brian M., Coden, Mackenzie E., Loffredo, Lucas F., Bhattacharyya, Swati, Chiarella, Sergio E., Varga, John, Abdala-Valencia, Hiam, Berdnikovs, Sergejs
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2018; Elsevier Limited
• Subjects: Animals; Bone marrow; Cell Differentiation - genetics; Cells, Cultured; Cloning; Eosinophils - physiology; Extracellular Matrix - metabolism; Extracellular Matrix Proteins - metabolism; Flow cytometry; Gene expression; Granulocyte Precursor Cells - physiology; Humans; Hypersensitivity - immunology; Leukocytes (eosinophilic); Lungs; Matrix protein; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphology; Nerve Tissue Proteins - metabolism; Pneumonia - immunology; Rodents; Tenascin; Tenascin - genetics; Tenascin - metabolism; Tenascin C

TNC is a hexabrachion featuring epidermal growth factor–like repeats, fibronectin type III (FN3)-like repeats, and a fibrinogen-like globe that interface integrins and other matrix components in tissues.3,E5,E6 Importantly, TNC is a known hematopoietic niche component in the bone marrow stroma.4,E7...