Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model

• Published in: Oncoimmunology Vol. 9; no. 1; p. 1758602
• Main Authors: Ye, Xuan, Waite, Janelle C., Dhanik, Ankur, Gupta, Namita, Zhong, Maggie, Adler, Christina, Malahias, Evangelia, Ni, Min, Wei, Yi, Gurer, Cagan, Zhang, Wen, Macdonald, Lynn E., Murphy, Andrew J., Sleeman, Matthew A., Skokos, Dimitris
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2020; Taylor & Francis Group
• Subjects: endogenous retrovirus; MC38; Original Research; p15E; single cell sequencing; TCR; tumor antigen; tumor antigen; TCR; p15E; endogenous retrovirus; single cell sequencing; m8; MC38

Clinical observations suggest that responses to cancer immunotherapy are correlated with intra-tumoral T cell receptor (TCR) clonality, tumor mutation burden (TMB) and host HLA genotype, highlighting the importance of host T cell recognition of tumor antigens. However, the dynamic interplay between...