Exosomal epidermal growth factor receptor is involved in HPV-16 E7-induced epithelial-mesenchymal transition of non-small cell lung cancer cells: A driver of signaling in vivo

• Published in: Cancer biology & therapy Vol. 23; no. 1; pp. 1 - 13
• Main Authors: Zhou, Zhiyuan, Wu, Xiaofeng, Zhan, Riming, Li, Xiangyong, Cheng, Dazhao, Chen, Li, Wang, Tianyu, Yu, Hua, Zhang, Guihong, Tang, Xudong
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2022; Taylor & Francis Group
• Subjects: Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Cell Line, Tumor; EGFR; EMT; Epithelial-Mesenchymal Transition - genetics; ErbB Receptors - genetics; Exosomes; Exosomes - metabolism; HPV-16 E7; Human papillomavirus 16; Humans; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; MicroRNAs - genetics; NSCLC; Papillomavirus E7 Proteins - genetics; Papillomavirus E7 Proteins - metabolism; Papillomavirus Infections - complications; Research Paper; HPV-16 E7; NSCLC; Exosomes; EMT; EGFR

Our previous studies have demonstrated that human papillomavirus (HPV)-16 E7 oncoprotein promoted epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) cells. Moreover, recent studies have found that exosomes can mediate EMT of NSCLC cells and epidermal growth factor receptor...