The toxicology mechanism of endophytic fungus and swainsonine in locoweed

• Published in: Environmental toxicology and pharmacology Vol. 47; pp. 38 - 46
• Main Authors: Wu, Chenchen, Han, Tiesuo, Lu, Hao, Zhao, Baoyu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2016; Elsevier Science Ltd
• Subjects: a-Mannosidase; Alkaloids; alpha-Mannosidase - classification; alpha-Mannosidase - metabolism; Animal; Animals; Ascomycota - metabolism; Ascomycota - physiology; Astragalus; Astragalus Plant - metabolism; Astragalus Plant - microbiology; Ataxia; Biodegradation; China; Degeneration; Economic impact; Endophytes; Endophytes - metabolism; Flowers & plants; Fungi; Gait; Glycoproteins; Livestock; Locoweed; Mannosidase; Mannosidases - antagonists & inhibitors; Oligosaccharides; Oxytropis; Oxytropis - metabolism; Oxytropis - microbiology; Plant Weeds - microbiology; Reproduction; Selenium; Selenium compounds; Staggering; Swainsonine; Swainsonine - metabolism; Swainsonine - pharmacokinetics; Swainsonine - toxicity; Symbiosis; Toxicity; Toxicology; China, People's Rep; Reproduction; Locoweed; Toxicity; Swainsonine; Animal

Locoweed is a perennial herbaceous plant included in Astragalus spp. and Oxytropis spp. that contains the toxic indolizidine alkaloid swainsonine. The livestock that consume locoweed can suffer from a type of toxicity called locoism. There are aliphaticnitro compounds, selenium, selenium compounds,...