David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors

• Published in: mAbs Vol. 14; no. 1; p. 2057832
• Main Authors: Alfaleh, Mohamed A., Zawawi, Ayat, Al-Amri, Sawsan S., Hashem, Anwar M.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2022; Taylor & Francis Group
• Subjects: ACE2; affinity maturation; Angiotensin-Converting Enzyme 2 - genetics; COVID-19; COVID-19 - drug therapy; Humans; immunoadhesins; Protein Binding; receptor traps; Receptors, Fc - metabolism; Review; SARS coronavirus 2; SARS-CoV-2; Spike Glycoprotein, Coronavirus - genetics; COVID-19; receptor traps; ACE2; SARS coronavirus 2; immunoadhesins; affinity maturation

Anti-SARS-CoV-2 monoclonal antibodies and vaccines have shown improvement in lowering viral burden and hospitalization. However, emerging SARS-CoV-2 variants contain neutralizing antibody-escape mutations. Therefore, several reports have suggested the administration of recombinant angiotensin-conver...