Insulin resistance and oxidative stress in familial combined hyperlipidemia

• Published in: Atherosclerosis Vol. 199; no. 2; pp. 384 - 389
• Main Authors: Martinez-Hervas, Sergio, Fandos, Marta, Real, Jose T., Espinosa, Olga, Chaves, F. Javier, Saez, Guillermo T., Salvador, Amparo, Cerdá, Concha, Carmena, Rafael, Ascaso, Juan F.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.08.2008; Elsevier
• Subjects: Adolescent; Adult; Aged; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - pathology; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular; Cardiovascular system; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - pharmacology; Familial combined hyperlipidemia; Female; Glutathione - metabolism; Glutathione Disulfide - metabolism; Humans; Hyperlipidemia, Familial Combined - metabolism; Insulin Resistance; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Lipids - chemistry; Male; Medical sciences; Middle Aged; Oxidative Stress; Oxidative stress; Insulin resistance; Familial combined hyperlipidemia; Atherosclerosis; Endocrinopathy; Vascular disease; Target tissue resistance; Metabolic diseases; Lipids; Cardiovascular disease; Hyperlipemia; Dyslipemia

Oxidative stress is associated with atherosclerosis. Familial combined hyperlipidemia (FCH) is considered as a human model of primary dyslipidemia and atherosclerosis frequently associated with insulin resistance (IR), but there are few data on its possible relation to oxidative stress. The objectiv...