Randomized controlled trial demonstrating the benefits of delta inulin adjuvanted immunotherapy in patients with bee venom allergy

• Published in: Journal of allergy and clinical immunology Vol. 144; no. 2; pp. 504 - 513.e16
• Main Authors: Heddle, Robert, Smith, Anthony, Woodman, Richard, Hissaria, Pravin, Petrovsky, Nikolai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019; Elsevier Limited; American Academy of Allergy, Asthma & Immunology
• Subjects: adjuvant; Adjuvants; Adjuvants, Immunologic - administration & dosage; Adult; Aged; Allergies; allergy; Anaphylaxis; Bee Venoms - administration & dosage; Bees; Female; Humans; Hymenoptera; Hypersensitivity - immunology; Hypersensitivity - pathology; Hypersensitivity - therapy; IgG4; Immunogenicity; Immunoglobulin E; Immunoglobulin E - immunology; Immunoglobulin G; Immunotherapy; Infectious diseases; Insect bites; Insect Bites and Stings - immunology; Insect Bites and Stings - pathology; Insect Bites and Stings - therapy; Inulin; Inulin - administration & dosage; Inulin - analogs & derivatives; Male; Middle Aged; Polysaccharides; Stings; Studies; Vaccines; Venom; United States > US; CRP; VIT; AHBVIT; IgG4; allergy; SARS; anaphylaxis; SHBVIT; inulin; HBVIT; adjuvant; WCC; immunotherapy; Hymenoptera; MCT; IgG

Allergic reactions to Hymenoptera insect stings remain a major global clinical problem. Although effective, parenteral desensitization regimens require use of costly venom extracts and require frequent visits over extended periods of time. Adjuvants are commonly used to enhance the efficacy of infec...