Talaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway

• Published in: Virulence Vol. 12; no. 1; pp. 1997 - 2012
• Main Authors: Wei, Wudi, Ning, Chuanyi, Huang, Jiegang, Wang, Gang, Lai, Jingzhen, Han, Jing, He, Jinhao, Zhang, Hong, Liang, Bingyu, Liao, Yanyan, Le, Thuy, Luo, Qiang, Li, Zhen, Jiang, Junjun, Ye, Li, Liang, Hao
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2021; Taylor & Francis Group
• Subjects: Cell Polarity; Humans; Immune Evasion; Immunity, Innate; M2 polarization; macrophages; Macrophages - immunology; Macrophages - microbiology; Mycoses - immunology; Research Paper; SOCS3; Suppressor of Cytokine Signaling 3 Protein - genetics; Suppressor of Cytokine Signaling 3 Protein - immunology; Talaromyces - genetics; Talaromyces - pathogenicity; Talaromyces marneffei; TLR9 pathway; Toll-Like Receptor 9 - immunology; SOCS3; TLR9 pathway; macrophages; Talaromyces marneffei; M2 polarization

Little is known about how Talaromyces marneffei, a thermally dimorphic fungus that causes substantial morbidity and mortality in Southeast Asia, evades the human immune system. Polarization of macrophages into fungal-inhibiting M1-like and fungal-promoting M2-like types has been shown to play an imp...