Role of silymarin as antioxidant in clinical management of chronic liver diseases: a narrative review

• Published in: Annals of medicine (Helsinki) Vol. 54; no. 1; pp. 1548 - 1560
• Main Authors: Aghemo, Alessio, Alekseeva, Olga P., Angelico, Francesco, Bakulin, Igor G., Bakulina, Natalia V., Bordin, Dmitry, Bueverov, Alexey O., Drapkina, Oxana M., Gillessen, Anton, Kagarmanova, Elvira M., Korochanskaya, Natalia V., Kucheryavii, U. A., Lazebnik, Leonid B., Livzan, Maria A., Maev, Igor V., Martynov, Anatolii I., Osipenko, Marina F., Sas, Evgenii I., Starodubova, Antonina, Uspensky, Yurii P., Vinnitskaya, Elena V., Yakovenko, Emilia P., Yakovlev, Alexey A.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 31.12.2022; Taylor & Francis Group
• Subjects: alcoholic fatty liver disease; Chronic liver disease; drug-induced liver injury; Gastroenterology & Hepatology; hepatoprotective and hepatotropic effects; metabolic-associated fatty liver disease; non-alcoholic fatty liver disease; oxidative stress; Review; silymarin; drug-induced liver injury; silymarin; non-alcoholic fatty liver disease; alcoholic fatty liver disease; hepatoprotective and hepatotropic effects; Chronic liver disease; metabolic-associated fatty liver disease; oxidative stress

Chronic liver disease (CLD), manifested as hepatic injury, is a major cause of global morbidity and mortality. CLD progresses to fibrosis, cirrhosis, and-ultimately-hepatocellular carcinoma (HCC) if left untreated. The different phenotypes of CLD based on their respective clinical features and causa...