A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

• Published in: Nature genetics Vol. 42; no. 6; pp. 515 - 519
• Main Authors: Kochi, Yuta, Okada, Yukinori, Suzuki, Akari, Ikari, Katsunori, Terao, Chikashi, Takahashi, Atsushi, Yamazaki, Keiko, Hosono, Naoya, Myouzen, Keiko, Tsunoda, Tatsuhiko, Kamatani, Naoyuki, Furuichi, Tatsuya, Ikegawa, Shiro, Ohmura, Koichiro, Mimori, Tsuneyo, Matsuda, Fumihiko, Iwamoto, Takuji, Momohara, Shigeki, Yamanaka, Hisashi, Yamada, Ryo, Kubo, Michiaki, Nakamura, Yusuke, Yamamoto, Kazuhiko
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.06.2010; Nature Publishing Group
• Subjects: 631/208/200; 631/208/205/2138; 631/208/727/2000; 692/699/249/1313/498; Agriculture; Animal Genetics and Genomics; Arthritis; Arthritis, Rheumatoid - genetics; Autoimmune diseases; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Disease susceptibility; Diseases of the osteoarticular system; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Function; Genetic aspects; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Human Genetics; Humans; Inflammatory joint diseases; Interleukin-17 - blood; letter; Medical sciences; Pathogenesis; Polymorphism, Genetic; Receptors, CCR6 - genetics; Receptors, CCR6 - metabolism; Regulatory Elements, Transcriptional; Rheumatism; Rheumatoid arthritis; Risk factors; Single nucleotide polymorphisms; Studies; Japan; Variant; Immunopathology; Chronic; Rheumatoid arthritis; Diseases of the osteoarticular system; Autoimmune disease; Inflammatory joint disease

Yuta Kochi and colleagues identify a regulatory variant in CCR6 associated with susceptibility to rheumatoid arthritis. CCR6 encodes a chemokine receptor expressed on a subset of helper T cells known as Th17 cells, suggesting a possible role for CCR6 in Th17-driven autoimmunity. Rheumatoid arthritis...