Synaptic protein CSF levels relate to memory scores in individuals without dementia

• Published in: Alzheimer's research & therapy Vol. 17; no. 1; pp. 56 - 15
• Main Authors: Wesenhagen, Kirsten E. J., de Leeuw, Diederick M., Tomassen, Jori, Gobom, Johan, Bos, Isabelle, Vos, Stephanie J. B., Martinez-Lage, Pablo, Tainta, Mikel, Popp, Julius, Peyratout, Gwendoline, Tsolaki, Magda, Vandenberghe, Rik, Freund-Levi, Yvonne, Verhey, Frans, Lovestone, Simon, Streffer, Johannes, Dobricic, Valerija, Blennow, Kaj, Scheltens, Philip, Smit, August B., Bertram, Lars, Teunissen, Charlotte E., Zetterberg, Henrik, Tijms, Betty M., Visser, Pieter Jelle
• Format: Journal Article
• Language: English
• Published: England BioMed Central 03.03.2025; BMC
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - cerebrospinal fluid; Biomarkers - cerebrospinal fluid; Cerebrospinal fluid proteomics; Cognitive Dysfunction - cerebrospinal fluid; Cognitive Dysfunction - psychology; Early Alzheimer’s disease; Female; Humans; Male; Memory - physiology; Memory Disorders - cerebrospinal fluid; Memory Disorders - etiology; Memory performance; Middle Aged; Neuropsychological Tests; Neurosciences; Neurovetenskaper; Synapses; Synaptic proteins; Cerebrospinal fluid proteomics; Memory performance; Early Alzheimer’s disease; Synaptic proteins

We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations. We included 242 CN (105(43%) abnormal amyloid), and 278 MCI indivi...