Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. We describe the pathological and molecular findings in a six-month-old asymptomatic cat w...
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| Published in | The journal of venomous animals and toxins including tropical diseases Vol. 28; p. e20210074 |
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| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Brazil
Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
2022
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) SciELO |
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| Abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs.
We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at
examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen.
The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR. |
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| AbstractList | Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. Case presentation: We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen. Conclusion: The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen. The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs.BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs.We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen.Case presentationWe describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen.The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.ConclusionThe present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR. |
| Author | Dutra, Valéria Colodel, Edson Moleta Pettan-Brewer, Christina Pereira, Asheley Henrique Barbosa Slhessarenko, Renata Dezengrini de Carvalho, Otávio Valério Dos Santos, Andrea Pires Hahn, Rosane Christine Souza, Valeria Regia Franco Biondo, Alexander Welker Kmetiuk, Louise Bach Ubiali, Daniel Guimarães Nakazato, Luciano de Morais, Helio Autran Jarrah, Samar Afif de Sousa, Alessandra Tammy Hayakawa Ito |
| AuthorAffiliation | 6 Júlio Muller University Hospital, Federal University of Mato Grosso, Cuiabá, MT, Brazil 4 Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, Washington, USA 7 Department of Epidemiology and Public Health, Veterinary Institute, Federal Rural University of Rio de Janeiro, Seropedica, RJ, Brazil 2 Graduate College of Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil 3 Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA 8 Department of Clinical Sciences, Oregon State University, Corvallis, OR, United States 9 Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, Brazil 1 Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MG, Brazil 5 Medical Science Faculty, Federal University of Mato Grosso, Cuiabá, MT, Brazil |
| AuthorAffiliation_xml | – name: 5 Medical Science Faculty, Federal University of Mato Grosso, Cuiabá, MT, Brazil – name: 3 Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA – name: 8 Department of Clinical Sciences, Oregon State University, Corvallis, OR, United States – name: 6 Júlio Muller University Hospital, Federal University of Mato Grosso, Cuiabá, MT, Brazil – name: 1 Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MG, Brazil – name: 2 Graduate College of Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – name: 7 Department of Epidemiology and Public Health, Veterinary Institute, Federal Rural University of Rio de Janeiro, Seropedica, RJ, Brazil – name: 4 Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, Washington, USA – name: 9 Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, Brazil – name: Federal University of Mato Grosso – name: Universidade Federal Rural do Rio de Janeiro – name: Purdue University – name: Federal University of Paraná – name: Oregon State University – name: University of Washington |
| Author_xml | – sequence: 1 givenname: Samar Afif surname: Jarrah fullname: Jarrah, Samar Afif organization: Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MG, Brazil – sequence: 2 givenname: Louise Bach surname: Kmetiuk fullname: Kmetiuk, Louise Bach organization: Graduate College of Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 3 givenname: Otávio Valério surname: de Carvalho fullname: de Carvalho, Otávio Valério organization: Graduate College of Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 4 givenname: Alessandra Tammy Hayakawa Ito surname: de Sousa fullname: de Sousa, Alessandra Tammy Hayakawa Ito organization: Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MG, Brazil – sequence: 5 givenname: Valeria Regia Franco surname: Souza fullname: Souza, Valeria Regia Franco organization: Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MG, Brazil – sequence: 6 givenname: Luciano surname: Nakazato fullname: Nakazato, Luciano organization: Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MG, Brazil – sequence: 7 givenname: Edson Moleta surname: Colodel fullname: Colodel, Edson Moleta organization: Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MG, Brazil – sequence: 8 givenname: Andrea Pires surname: Dos Santos fullname: Dos Santos, Andrea Pires organization: Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA – sequence: 9 givenname: Christina surname: Pettan-Brewer fullname: Pettan-Brewer, Christina organization: Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, Washington, USA – sequence: 10 givenname: Rosane Christine surname: Hahn fullname: Hahn, Rosane Christine organization: Medical Science Faculty, Federal University of Mato Grosso, Cuiabá, MT, Brazil – sequence: 11 givenname: Renata Dezengrini surname: Slhessarenko fullname: Slhessarenko, Renata Dezengrini organization: Júlio Muller University Hospital, Federal University of Mato Grosso, Cuiabá, MT, Brazil – sequence: 12 givenname: Daniel Guimarães surname: Ubiali fullname: Ubiali, Daniel Guimarães organization: Department of Epidemiology and Public Health, Veterinary Institute, Federal Rural University of Rio de Janeiro, Seropedica, RJ, Brazil – sequence: 13 givenname: Asheley Henrique Barbosa orcidid: 0000-0001-9704-9801 surname: Pereira fullname: Pereira, Asheley Henrique Barbosa organization: Department of Epidemiology and Public Health, Veterinary Institute, Federal Rural University of Rio de Janeiro, Seropedica, RJ, Brazil – sequence: 14 givenname: Helio Autran surname: de Morais fullname: de Morais, Helio Autran organization: Department of Clinical Sciences, Oregon State University, Corvallis, OR, United States – sequence: 15 givenname: Alexander Welker orcidid: 0000-0002-4182-5821 surname: Biondo fullname: Biondo, Alexander Welker organization: Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 16 givenname: Valéria surname: Dutra fullname: Dutra, Valéria organization: Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MG, Brazil |
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| Keywords | Pets Cats SARS-CoV-2 Coronavirus Disease transmission |
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| Notes | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Report-1 Competing interests: The authors declare that they have no competing interests. Authors’ contributions: SAJ, ATHIS and VRFS performed data collection, clinical evaluation and contributed to the Results and Discussion sections of the manuscript. EMC performed necropsy and was in charge of the Results and Discussion sections of the manuscript. DGU and AHBP performed histopathology and immunohistochemistry analyses and wrote the Results and Discussion sections of the manuscript. OVC, LN and VD performed molecular analyses of animal samples, and wrote the Results and Discussion sections of the manuscript. RCH and RDS performed molecular analyses of owner samples, and wrote the Results and Discussion sections of the manuscript. LBK, APS, CPB, HAM and AWB wrote the first draft and participated in all sections of the manuscript. All authors read and approved the final manuscript. |
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Gaudreault; Trujillo, JD; Carossino, M; Meekins, DA; Morozov, I; Madden, DW; Indran, SV; Bold, D; Balaraman, V; Kwon, T; Artiaga, BL; Cool, K; Garcia-Sastre, A; Ma, W; Wilson, WC; Henningson, J; Balasuriya, UBR; Richt, JA – volume: 368 start-page: 1016 issue: 6494 year: 2020 end-page: 1020 article-title: Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 publication-title: Science contributor: fullname: Shi, J; Wen, Z; Zhong, G; Yang, H; Wang, C; Huang, B; Liu, R; He, X; Shuai, L; Sun, Z; Zhao, Y; Liu, P; Liang L Cui, P; Wang, J; Zhang, X; Guan, Y; Tan, W; Wu, G; Chen, H; Bu, Z – volume: 33 start-page: 2104 issue: 11 year: 2020 end-page: 2114 article-title: In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19 publication-title: Mod Pathol contributor: fullname: Schaefer, I-M; Padera, RF; Solomon, IH; Kanjilal, S; Hammer, MM; Hornick, JL; Sholl, LM – volume: 6 start-page: 73 issue: 1 year: 2020 end-page: 86 article-title: Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets publication-title: Nat Microbiol contributor: fullname: Singh, DK; Singh, B; Ganatra, SR; Gazi, M; Cole, J; Thippeshappa, R – volume: 585 start-page: 268 issue: 7824 year: 2020 end-page: 272 article-title: Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 publication-title: Nature contributor: fullname: Munster, VJ; Feldmann, F; Williamson, BN; van Doremalen, N; Pérez-Pérez, L; Schulz, J; Meade-White, K; Okumura, A; Callison, J; Brumbaugh, B; Avanzato, VA; Rosenke, R; Hanley, PW; Saturday, G; Scott, D; Fischer, ER; de Wit, E – year: 2020 publication-title: Neuropathology and Virus in Brain of SARS-CoV-2 Infected Non-Human Primates contributor: fullname: Fischer, T; Rutkai, I; Mayer, M; Hellmers, L; Ning, B; Huang, Z; Monjure, C; Coyne, C; Silvestri, R; Golden, N; Hensley, K; Chandler, K; Lehmicke, G; Bix, G; Maness, N; Russel-Lodrigue, K; Hu, T; Roy, C; Blair, R; Bohm, R; Doyle-Meyers, L; Rappaport, J; Fischer, T – publication-title: COVID-19 - OIE - World Organisation for Animal Health – volume: 27 start-page: 660 issue: 2 year: 2021 end-page: 663 article-title: Protective Immunity and Persistent Lung Sequelae in Domestic Cats after SARS-CoV-2 Infection publication-title: Emerg Infect Dis contributor: fullname: Chiba, S; Halfmann, PJ; Hatta, M; Maemura, T; Fan, S; Armbrust, T; Swartley, OM; Crawford, LK; Kawaoka, Y – volume: 30 start-page: 708 year: 2020 end-page: 710 article-title: Pulmonary alveolar regeneration in adult COVID-19 patients publication-title: Cell Res contributor: fullname: Chen, J; Wu, H; Yu, Y; Tang, N – volume: 34 start-page: 1614 issue: 9 year: 2021 end-page: 1633 article-title: Histopathological findings and clinicopathologic correlation in COVID-19: a systematic review publication-title: Mod Pathol contributor: fullname: Caramaschi, S; Kapp, ME; Miller, SE; Eisenberg, R; Johnson, J; Epperly, G; Maiorana, A; Silvestri, G; Giannico, G – volume: 7 year: 2020 article-title: Natural Infection by SARS-CoV-2 in Companion Animals: A Review of Case Reports and Current Evidence of Their Role in the Epidemiology of COVID-19 publication-title: Front Vet Sci contributor: fullname: de Morais, HA; dos Santos, AP; do Nascimento, NC; Kmetiuk, LB; Barbosa, DS; Brandão, PE; Guimarães, MAS; Pettan-Brewer, C; Biondo, AW – volume: 33 start-page: 2092 year: 2020 end-page: 2103 article-title: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers publication-title: Mod Pathol contributor: fullname: Hecht, JL; Quade, B; Deshpande, V; Mino-Kenudson, M; Ting, DT; Desai, N; Dygulska, B; Heyman, T; Salafia, C; Shen, D; Bates, SV; Roberts, DJ – volume: 11 issue: 1 year: 2020 article-title: SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication publication-title: Nat Commun contributor: fullname: Alexandersen, S; Chamings, A; Bhatta, TR – year: 2021 article-title: Determining the Role of Natural SARS-CoV-2 Infection in the Death of Ten Domestic Pets publication-title: Research Square contributor: fullname: Carpenter, A; Ghai, R; Gary, J; Ritter, J; Carvallo, F; Diel, D; Martins, M; Murphy, J; Schroeder, B; Brightbill, K; Tewari, D; Boger, L; Gabel, J; Cobb, R; Hennebelle, J; Stanton, JB; McCullough, K – volume: 117 start-page: 24790 issue: 40 year: 2020 end-page: 24793 article-title: Detection of SARS-CoV-2 in a cat owned by a COVID-19-affected patient in Spain publication-title: Proc Natl Acad Sci U S A contributor: fullname: Segalés, J; Puig, M; Rodon, J; Avila-Nieto, C; Carrillo, J; Cantero, G; Terrón, MT; Cruz, S; Parera, M; Noguera-Julian, M; Izquierdo-Useros, N; Guallar, V; Vidal, E; Valencia, A; Blanco, I; Blanco, J; Clotet, B; Vergara-Alert, J – volume: 27 start-page: 123 issue: 3 year: 2020 end-page: 127 article-title: Histopathology features of the lung in COVID-19 patients publication-title: Diagn Histopathol (Oxf) contributor: fullname: Montero-Fernández, MA; Pardo-Garcia, R – volume: 2 start-page: 639 issue: 4 year: 2021 end-page: 652 article-title: COVID-19-associated nephropathy includes tubular necrosis and capillary congestion, with evidence of SARS-CoV-2 in the nephron publication-title: Kidney360 contributor: fullname: Bouquegneau, A; Erpicum, P; Grosch, S; Habran, L; Hougrand, O; Huart, J; Krzesinski, JM; Misset, B; Hayette, MP; Delvenne, P; Bovy, C; Kylies, D – volume: 12 year: 2020 publication-title: Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection contributor: fullname: Diao, B; Wang, C; Wang, R; Feng, Z; Tan, Y; Wang, H; Wang, C; Liu, L; Liu, Y; Liu, Y; Wang, G; Yuan, Z; Hou, X; Ren, L; Wu, Y; Chen, Y |
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| Title | Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil |
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