Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls

• Published in: Gut microbes Vol. 13; no. 1; p. 1941711
• Main Authors: Gheorghe, Cassandra E., Ritz, Nathaniel L., Martin, Jason A., Wardill, Hannah R., Cryan, John F., Clarke, Gerard
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2021; Taylor & Francis Group
• Subjects: Animal Experimentation - standards; Animals; antibiotics; Disease Models, Animal; experimental design; Fecal microbiota transplantation; Fecal Microbiota Transplantation - standards; Feces - microbiology; Gastrointestinal Microbiome; germ-free; Germ-Free Life; gnotobiotic; Guidelines as Topic; human; Humans; methods; microbiota depletion; Review; rodent; Rodentia - microbiology; germ-free; Fecal microbiota transplantation; methods; rodent; gnotobiotic; experimental design; antibiotics; human; microbiota depletion

In recent years, studies investigating the role of the gut microbiota in health and diseases have increased enormously - making it essential to deepen and question the research methodology employed. Fecal microbiota transplantation (FMT) in rodent studies (either from human or animal donors) allows...