Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers

• Published in: Drug metabolism and disposition Vol. 38; no. 5; pp. 781 - 788
• Main Authors: Hostler, David, Zhou, Jiangquan, Tortorici, Michael A., Bies, Robert R., Rittenberger, Jon C., Empey, Philip E., Kochanek, Patrick M., Callaway, Clifton W., Poloyac, Samuel M.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.05.2010; American Society for Pharmacology and Experimental Therapeutics; The American Society for Pharmacology and Experimental Therapeutics
• Subjects: Adult; Area Under Curve; Biological and medical sciences; Body Temperature - drug effects; Computer Simulation; Cross-Over Studies; Cytochrome P-450 CYP3A - metabolism; Heart Rate - drug effects; Humans; Hypothermia - chemically induced; Hypothermia - metabolism; Infusions, Intravenous; Magnesium Sulfate - administration & dosage; Magnesium Sulfate - pharmacology; Male; Medical sciences; Midazolam - analogs & derivatives; Midazolam - metabolism; Midazolam - pharmacokinetics; Models, Biological; Pharmacokinetics; Pharmacology. Drug treatments; Sodium Chloride - administration & dosage; Sodium Chloride - pharmacology; Temperature; Young Adult; TEM; MS; CI; OFV; LC; AUC; Human; Healthy subject; Psychotropic; Benzodiazepine derivatives; Hypnotic; Midazolam; Sedative; Pharmacokinetics; Hypothermia

The clinical use of therapeutic hypothermia has been rapidly expanding due to evidence of neuroprotection. However, the effect of hypothermia on specific pathways of drug elimination in humans is relatively unknown. To gain insight into the potential effects of hypothermia on drug metabolism and dis...