Cholesterol efflux pathways, inflammation, and atherosclerosis

• Published in: Critical reviews in biochemistry and molecular biology Vol. 56; no. 4; pp. 426 - 439
• Main Authors: Groenen, Anouk G., Halmos, Benedek, Tall, Alan R., Westerterp, Marit
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.07.2021
• Subjects: Animals; Atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - metabolism; Atherosclerosis - pathology; Biological Transport, Active - genetics; cardiovascular diseases; Cell Proliferation; cholesterol efflux; Cholesterol, HDL - genetics; Cholesterol, HDL - metabolism; Gene Expression Regulation; Hematopoietic Stem Cells - metabolism; Hematopoietic Stem Cells - pathology; high-density lipoprotein; Humans; Inflammasomes; inflammation; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Liver X Receptors - genetics; Liver X Receptors - metabolism; Mendelian Randomization Analysis; RNA-Seq; Single-Cell Analysis; cardiovascular diseases; cholesterol efflux; inflammation; high-density lipoprotein; Atherosclerosis

Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol levels and CVD has been called into question by Mendelian randomization studies and the majority of clinical trials not show...