Complement C1q essential for aeroallergen sensitization via CSF1R+ conventional dendritic cells type 2

• Published in: Journal of allergy and clinical immunology Vol. 152; no. 5; pp. 1141 - 1152.e2
• Main Authors: Moon, Hyung-Geun, Eccles, Jacob D., Kim, Seung-jae, Kim, Ki-Hyun, Kim, Young-Mee, Rehman, Jalees, Lee, Hyun, Kanabar, Pinal, Christman, John W., Ackerman, Steven J., Ascoli, Christian, Kang, Homan, Choi, Hak Soo, Kim, Minhyung, You, Sungyong, Park, Gye Young
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2023; Elsevier
• Subjects: allergen sensing; Allergens - metabolism; allergic asthma; Animals; Asthma - metabolism; Colony stimulating factor 1 receptor (CSF1R); Complement C1q - metabolism; complement component 1q (C1q); conventional dendritic cell type 2 (cDC2); Dendritic Cells; Humans; Mice; Mice, Knockout; Pneumonia - metabolism; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor - metabolism; UMAP; cDC; tSNE; allergen sensing; Colony stimulating factor 1 receptor (CSF1R); conventional dendritic cell type 2 (cDC2); FACS; BAL; ES; HDM; DRA; moDC; scRNA-seq; allergic asthma; SBP-AG; ZW; complement component 1q (C1q); DC

Dendritic cells (DCs) are heterogeneous, comprising multiple subsets with unique functional specifications. Our previous work has demonstrated that the specific conventional type 2 DC subset, CSF1R+cDC2s, plays a critical role in sensing aeroallergens. It remains to be understood how CSF1R+cDC2s rec...