Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects

• Published in: Atherosclerosis Vol. 193; no. 1; pp. 159 - 167
• Main Authors: Cazzola, Roberta, Russo-Volpe, Samantha, Miles, Elizabeth A., Rees, Dinka, Banerjee, Tapati, Roynette, Catherine E., Wells, Solenne J., Goua, Marie, Wahle, Klaus W.J., Calder, Philip C., Cestaro, Benvenuto
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.07.2007; Elsevier
• Subjects: Adhesion molecules; Adolescent; Adult; Age Factors; Aged; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood lipids; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - prevention & control; Cardiovascular system; Copper - pharmacology; Coronary heart disease; Double-Blind Method; E-Selectin - blood; Eicosapentaenoic Acid - administration & dosage; Eicosapentaenoic Acid - adverse effects; Fish oil; Fish Oils - administration & dosage; Fish Oils - adverse effects; Glutathione - blood; Glutathione Disulfide - blood; Heart; Humans; Intercellular Adhesion Molecule-1 - blood; Lipid Peroxides - blood; Lipids - blood; Male; Medical sciences; Middle Aged; Oxidative Stress; Pharmacology. Drug treatments; Polyunsaturated fatty acid; Risk Factors; Vasodilator agents. Cerebral vasodilators; Polyunsaturated fatty acid; Oxidative stress; Cardiovascular disease; Adhesion molecules; Blood lipids; Fish oil; E Selectin; Lipids; Lipoprotein; n-3 fatty acid; Dose activity relation; Vascular disease; Triacylglycerol; Cholesterol HDL; Atherosclerosis; Arterial pressure; Blood pressure; Supplementation; Copper; Glutathione; Peroxidation; Human; Intercellular adhesion molecule 1; Cholesterol LDL; Risk factor; Unsaturated fatty acid; Hemodynamics; Eicosapentaenoic acid

Supplementation with fish oils, rich in n − 3 polyunsaturated fatty acids, modifies cardiovascular risk factors. However, dose–response relationships are poorly defined and whether similar effects are seen in young and older subjects is not known. This study determined the effect of supplementing th...