Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on Clostridioides difficile

• Published in: Gut microbes Vol. 13; no. 1; p. 1979882
• Main Authors: Chandra, Harish, Sharma, Krishna Kant, Tuovinen, Olli H., Sun, Xingmin, Shukla, Pratyoosh
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2021; Taylor & Francis Group
• Subjects: Animals; Clostridioides difficile - genetics; Clostridioides difficile - growth & development; Clostridioides difficile - physiology; Clostridium Infections - diagnosis; Clostridium Infections - immunology; Clostridium Infections - microbiology; Clostridium Infections - therapy; Dysbiosis; Gastrointestinal Microbiome; Host-Pathogen Interactions; Humans; inflammasome; inflammatory bowel disease; innate lymphoid cells; pseudomembranous colitis; Review; Th17 Cells - immunology; toxins; pseudomembranous colitis; innate lymphoid cells; Dysbiosis; inflammasome; inflammatory bowel disease; toxins

Pathobionts are opportunistic microbes that emerge as a result of perturbations in the healthy microbiome due to complex interactions of various genetic, exposomal, microbial, and host factors that lead to their selection and expansion. Their proliferations can aggravate inflammatory manifestations,...