Hematopoietic stem cell transplantation in patients with gain-of-function signal transducer and activator of transcription 1 mutations - Leiding, Jennifer W.; Okada, Satoshi; Hagin, David; Abinun, Mario; Shcherbina, Anna; Balashov, Dmitry N.; Kim, Vy H.D.; Ovadia, Adi; Guthery, Stephen L.; Pulsipher, Michael; Lilic, Desa; Devlin, Lisa A.; et al. (Journal of allergy and clinical immunology, 2018)
Keywords: Allografts; Autoimmune diseases; Autoimmunity; Bacterial infections; Bone marrow; chronic mucocutaneous candidiasis; Cloning; Cytokines; Deoxyribonucleic acid; Disease-Free Survival; DNA; Female; gain of function; Gain of Function Mutation; Genetic Predisposition to Disease; Genotype & phenotype; Graft rejection; Graft versus host disease; Graft vs Host Disease - genetics; Graft vs Host Disease - immunology; Graft vs Host Disease - mortality; Graft-versus-host reaction; Grafts; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; hemophagocytic lymphohistiocytosis; Histiocytosis; Human subjects; Humans; Immunodeficiency; Infections; Janus kinase; Kinases; Lymphocytosis; Male; Mutagenesis; Mutation; Patients; Phosphorylation; Plasmids; Retrospective Studies; Risk Factors; signal transducer and activator of transcription; Stat1 protein; STAT1 Transcription Factor - genetics; STAT1 Transcription Factor - immunology; Stem cell transplantation; Stem cells; Survival analysis; Survival Rate; Transcription; Transplants & implants; HLH; hemophagocytic lymphohistiocytosis; MMUD; chronic mucocutaneous candidiasis; signal transducer and activator of transcription; EFS; CMC; Janus kinase; HSCT; MUD; WT; Hematopoietic stem cell transplantation; CID; GOF; graft rejection; OS; KREC; PBSC; RIC; STAT; JAK; UCB; gain of function; GAS; IPEX; TREC; NK; graft-versus-host disease; MRD