Ohmyungsamycin promotes M1-like inflammatory responses to enhance host defence against Mycobacteroides abscessus infections

• Published in: Virulence Vol. 13; no. 1; pp. 1966 - 1984
• Main Authors: Jeon, Sang Min, Kim, Young Jae, Nguyen, Thanh Quang, Cui, Jinsheng, Thi Bich Hanh, Bui, Silwal, Prashanta, Kim, Jin Kyung, Kim, Jin-Man, Oh, Dong-Chan, Jang, Jichan, Jo, Eun-Kyeong
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2022; Taylor & Francis Group
• Subjects: Animals; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Humans; innate immunity; M1 macrophage responses; Macrophages - microbiology; Mice; mitochondrial reactive oxygen species; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous - metabolism; Mycobacteroides abscessus; nitric oxide; Ohmyungsamycins; Research Paper; Zebrafish; nitric oxide; M1 macrophage responses; innate immunity; mitochondrial reactive oxygen species; Mycobacteroides abscessus; Ohmyungsamycins

Ohmyungsamycin A (OMS) is a newly identified cyclic peptide that exerts antimicrobial effects against Mycobacterium tuberculosis. However, its role in nontuberculous mycobacteria (NTMs) infections has not been clarified. Mycobacteroides abscessus (Mabc) is a rapidly growing NTM that has emerged as a...