Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis

• Published in: Annals of medicine (Helsinki) Vol. 53; no. 1; pp. 43 - 69
• Main Authors: Borrajo, A., Spuch, C., Penedo, M. A., Olivares, J. M., Agís-Balboa, R. C.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2021; Taylor & Francis Group
• Subjects: Anti-retroviral therapy (ART); Chemokines (or chemotactic cytokines); HIV-1-associated neurocognitive disorders (HAND); Human immunodeficiency virus type 1 (HIV-1); Immunology; Microglia; Reactive oxygen species (ROS); Review; Chemokines (or chemotactic cytokines); Human immunodeficiency virus type 1 (HIV-1); HIV-1-associated neurocognitive disorders (HAND); Anti-retroviral therapy (ART); Reactive oxygen species (ROS); Microglia

The development of effective combined anti-retroviral therapy (cART) led to a significant reduction in the death rate associated with human immunodeficiency virus type 1 (HIV-1) infection. However, recent studies indicate that considerably more than 50% of all HIV-1 infected patients develop HIV-1-a...