Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice

• Published in: Autophagy Vol. 16; no. 11; pp. 2084 - 2097
• Main Authors: Mareninova, Olga A., Jia, Wenzhuo, Gretler, Sophie R., Holthaus, Conner L., Thomas, Diana D. H., Pimienta, Michael, Dillon, Dustin L., Gukovskaya, Anna S., Gukovsky, Ilya, Groblewski, Guy E.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.11.2020
• Subjects: ATG4B; ATG8; autophagic flux; LC3B; pancreatic acinar cell; Research Paper; autophagic flux; pancreatic acinar cell; ATG4B; ATG8; LC3B

Pancreatitis is a common, sometimes fatal, disease of exocrine pancreas, initiated by damaged acinar cells. Recent studies implicate disordered macroautophagy/autophagy in pancreatitis pathogenesis. ATG8/LC3 protein is critical for autophagosome formation and a widely used marker of autophagic vacuo...