Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening

• Published in: Autophagy Vol. 16; no. 3; pp. 451 - 465
• Main Authors: Deng, Jiali, Guo, Yajie, Yuan, Feixiang, Chen, Shanghai, Yin, Hanrui, Jiang, Xiaoxue, Jiao, Fuxin, Wang, Fenfen, Ji, Hongbin, Hu, Guohong, Ying, Hao, Chen, Yan, Zhai, Qiwei, Xiao, Fei, Guo, Feifan
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.03.2020
• Subjects: Adipogenesis - drug effects; Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - metabolism; Adipose Tissue, White - drug effects; Adipose Tissue, White - metabolism; Adiposity - drug effects; Animals; Animals, Newborn; ATG7; Autophagy; Autophagy-Related Protein 7 - genetics; Autophagy-Related Protein 7 - metabolism; BAT whitening; BTG1; Cell Line; Cyclic AMP Response Element-Binding Protein - metabolism; Dexamethasone - pharmacology; Gene Expression Regulation - drug effects; Gene Knockdown Techniques; glucocorticoid; Glucocorticoids - pharmacology; Humans; Lipids - chemistry; Male; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Research Paper; glucocorticoid; BAT whitening; BTG1; autophagy; ATG7

The mechanisms underlying glucocorticoid (GC)-increased adiposity are poorly understood. Brown adipose tissue (BAT) acquires white adipose tissue (WAT) cell features defined as BAT whitening under certain circumstances. The aim of our current study was to investigate the possibility and mechanisms o...