Immunological efficacy of glypican-3 peptide vaccine in patients with advanced hepatocellular carcinoma

• Published in: Oncoimmunology Vol. 6; no. 10; p. e1346764
• Main Authors: Tsuchiya, Nobuhiro, Yoshikawa, Toshiaki, Fujinami, Norihiro, Saito, Keigo, Mizuno, Shoichi, Sawada, Yu, Endo, Itaru, Nakatsura, Tetsuya
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.10.2017; Taylor & Francis Group
• Subjects: CTL; Glypican-3 (GPC3); HCC; immunological efficacy; Original Research; Peptide vaccine; HCC; CTL; Glypican-3 (GPC3); Peptide vaccine; immunological efficacy

We have previously conducted a phase I trial to test the efficacy of a glypican-3 (GPC3) peptide vaccine in patients with advanced hepatocellular carcinoma (HCC); however, its immunological mechanism of action remains unclear. Here, we report a pilot study conducted to evaluate the immunological mec...