HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes - Ooi, Jenny Y Y; Tuano, Natasha K; Rafehi, Haloom; Gao, Xiao-Ming; Ziemann, Mark; Du, Xiao-Jun; El-Osta, Assam (Epigenetics, 2015)
Keywords: Acetylation - drug effects; Animals; Aorta - surgery; cardiac hypertrophy; Cardiomegaly - genetics; Cardiomegaly - metabolism; Cardiomegaly - surgery; chromatin; epigenetics; Gene Expression Regulation - drug effects; HDAC inhibitor; histone acetylation; Histone Deacetylase Inhibitors - pharmacology; Histone Deacetylases - metabolism; Histones - metabolism; Hydroxamic Acids - pharmacology; Male; Mice, Inbred C57BL; Myocardium - metabolism; next generation sequencing; NF-kappa B - metabolism; Research Paper; NFκB, Nuclear factor of kappa light polypeptide gene enhancer in B-cells; Icam1, Intercellular adhesion molecule 1; LVH, Left Ventricle Hypertrophy; cDNA, complementary DNA; TF, transcription factor; Il21r, Interleukin-21 receptor; Serca2a, Sarcoplasmic reticulum Ca2+ ATPase; TSS, Transcription Start Site; epigenetics; SEM, Standard Error of the Mean; BW, Body Weight; Il6ra, Interleukin-6 receptor; Cxcl10, Chemokine (C-X-C Motif) ligand 10; FDR, False Discovery Rate; NES, normalized enrichment score; TAC, Transverse Aortic Constriction; MACs, Model-based Analysis of ChIP-seq; GAIIx, Genome Analyzer IIx; Traf3, TNF receptor-associated factor 3; BNP, Brain natriuretic peptide; ChIP, Chromatin Immunoprecipitation; next generation sequencing; NGS, Next Generation Sequencing; chromatin; HDAC, Histone deacetylase; Vcam1, Vascular cell adhesion molecule 1; Ct, threshold cycle number; TAC veh, TAC vehicle; ANP, Atrial natriuretic peptide; TSA, Trichostatin A; HDAC inhibitor; α/βMHC, Alpha/Beta myosin heavy chain; ENCODE, Encyclopedia of DNA Elements Consortium; FS, Fractional Shortening; LVDd, Left Ventricular Diastolic Dimension; UTR, Untranslated region; cardiac hypertrophy; Ticam2, Toll-like receptor adaptor molecule 2; histone acetylation; LV, Left Ventricle; TL, Tibia Length