The influence of selenium-enriched milk proteins and selenium yeast on plasma selenium levels and rectal selenoprotein gene expression in human subjects

• Published in: British journal of nutrition Vol. 106; no. 4; pp. 572 - 582
• Main Authors: Hu, Ying, McIntosh, Graeme H., Le Leu, Richard K., Upton, Jane M., Woodman, Richard J., Young, Graeme P.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.08.2011; CABI Pub
• Subjects: Aged; Australia; Australia - epidemiology; Biological and medical sciences; Biopsy; blood; chemistry; Colorectal carcinoma; colorectal neoplasms; Colorectal Neoplasms - epidemiology; dairy protein; deficiency; Dietary Supplements; Double-Blind Method; epidemiology; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; gastrointestinal system; Gene expression; Gene Expression Regulation; genes; genetics; glutathione peroxidase; Glutathione Peroxidase - blood; Glutathione Peroxidase - genetics; Glutathione Peroxidase - metabolism; Human and Clinical Nutrition; Humans; Male; messenger RNA; metabolism; Middle Aged; Milk; milk proteins; Milk Proteins - chemistry; Milk Proteins - therapeutic use; pathology; Proteins; Rectum; Rectum - metabolism; Rectum - pathology; risk; Risk Factors; RNA, Messenger; RNA, Messenger - metabolism; Selenium; Selenium - blood; Selenium - deficiency; Selenium - therapeutic use; Selenoprotein P; Selenoprotein P - genetics; Selenoprotein P - metabolism; selenoproteins; Selenoproteins - genetics; Selenoproteins - metabolism; Severity of Illness Index; therapeutic use; Vertebrates: anatomy and physiology, studies on body, several organs or systems; volunteers; Yeast, Dried; Yeast, Dried - chemistry; Yeast, Dried - therapeutic use; Yeasts; Australia; Selenium; Selenoproteins; Rectal biopsy; Colorectal cancer prevention; Colorectal cancer; Health benefits; Human; Rectal disease; Yeast; Health; Malignant tumor; Gene expression; Blood plasma; Colonic disease; Prevention; Vertebrata; Milk protein; Selenoprotein; Mammalia; Biopsy; Rectum; Digestive diseases; Intestinal disease; Cancer

Certain forms of dietary Se may have advantages for improving human Se status and regulating the risk for disease, such as cancers, including colorectal cancer (CRC). The present study compared the effects of a Se-enriched milk protein (dairy-Se) with a Se-rich yeast (yeast-Se) on plasma Se levels a...