Gene expression signatures of angiocidin and darapladib treatment connect to therapy options in cervical cancer

• Published in: Journal of cancer research and clinical oncology Vol. 139; no. 2; pp. 259 - 267
• Main Authors: Koch, Martin, Wiese, Michael
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2013; Springer; Springer Nature B.V
• Subjects: Adult; Aged; Antineoplastic agents; Antineoplastic Agents - therapeutic use; Benzaldehydes - therapeutic use; Biological and medical sciences; Biomarkers, Tumor - genetics; Biopsy; Cancer Research; Cancer therapies; Cervical cancer; Cluster Analysis; DNA microarrays; Extracellular matrix; Female; Female genital diseases; Gene expression; Gene Expression Regulation, Neoplastic; Gene set enrichment analysis; Graft-versus-host reaction; Gynecology. Andrology. Obstetrics; Hematology; Human papillomavirus; Humans; Immunological diseases; Internal Medicine; Kidney transplantation; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasm Staging; Oncology; Original Paper; Oximes - therapeutic use; Pharmacology. Drug treatments; Probes; Proteasome Endopeptidase Complex - therapeutic use; RNA-Binding Proteins; Transcriptome; Tumors; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - pathology; Angiocidin; Darapladib; Cervical cancer; AURKA; Treatment; Malignant tumor; Uterine cervix; Gene expression; Uterine cervix diseases; Cancer; Female genital diseases; Gene expression profile

Purpose To assign functional properties to gene expression profiles of cervical cancer stages and identify clinically relevant biomarker genes. Experimental design Microarray samples of 24 normal and 102 cervical cancer biopsies from four publicly available studies were pooled and evaluated. High-qu...