Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

• Published in: Gut microbes Vol. 12; no. 1; p. 1832857
• Main Authors: Ma, Lingyan, Ni, Yinhua, Wang, Zhe, Tu, Wenqing, Ni, Liyang, Zhuge, Fen, Zheng, Aqian, Hu, Luting, Zhao, Yufeng, Zheng, Liujie, Fu, Zhengwei
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 09.11.2020; Taylor & Francis Group
• Subjects: gut microbiota; insulin resistance; intestinal barrier function; Research Paper; short-chain fatty acid; Spermidine; short-chain fatty acid; intestinal barrier function; insulin resistance; Spermidine; gut microbiota

Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important benefits in patients with aging-associated diseases and metabolic dysfunction. However, the mechanism of spermidine on obesity...