Decreased Monocyte HLA-DR Expression in Patients with Sepsis and Acute Kidney Injury

• Published in: Medicina (Kaunas, Lithuania) Vol. 58; no. 9; p. 1198
• Main Authors: Wu, Huang-Pin, Chuang, Li-Pang, Liu, Pi-Hua, Chu, Chien-Ming, Yu, Chung-Chieh, Lin, Shih-Wei, Kao, Kuo-Chin, Li, Li-Fu, Chuang, Duen-Yau
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2022; MDPI
• Subjects: acute kidney injury; Age; Antigens; Blood pressure; Chronic kidney failure; Creatinine; Health aspects; Hemodialysis; Histocompatibility antigens; HLA histocompatibility antigens; HLA-DR; Hypotension; Infections; Kidneys; Ligands; Measurement; monocyte; Monocytes; Mortality; Plasma; Risk factors; Sepsis; Statistical analysis; Taiwan; United States > US

Background and objectives: Acute kidney injury (AKI) is common in critically ill patients, especially those with sepsis. Persistently low human leukocyte antigen (HLA)-DR expression in monocytes reflects the decreased function of antigen-presenting cells, contributing to poor outcomes in sepsis. Thi...