The rs17084733 variant in the KIT 3' UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility - Ravegnini, Gloria; Serrano, César; Simeon, Vittorio; Sammarini, Giulia; Nannini, Margherita; Roversi, Erica; Urbini, Milena; Ferrè, Fabrizio; Ricci, Riccardo; Tarantino, Giuseppe; Pantaleo, Maria A.; Hrelia, Patrizia; et al. (Epigenetics, 2019)
Keywords: 3' Untranslated Regions - genetics; Adult; Aged; Aged, 80 and over; Apoptosis; Binding Sites; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Case-Control Studies; Cell Proliferation; Disease Susceptibility; epigenetics; Female; Follow-Up Studies; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - metabolism; Gastrointestinal Neoplasms - pathology; gastrointestinal stromal tumor; Gastrointestinal Stromal Tumors - genetics; Gastrointestinal Stromal Tumors - metabolism; Gastrointestinal Stromal Tumors - pathology; Gene Expression Regulation, Neoplastic; GIST; Humans; imatinib; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miR-221/222; miRNA sponge; miRSNP; Polymorphism, Single Nucleotide; Prognosis; Proto-Oncogene Proteins c-kit - genetics; Proto-Oncogene Proteins c-kit - metabolism; Research Paper; Retrospective Studies; SNP; Survival Rate; Tumor Cells, Cultured; Young Adult; miRNA sponge; miRSNP; GIST; SNP; gastrointestinal stromal tumor; KIT; imatinib; epigenetics; miR-221/222