The Electrophysiologic Effects of Acute Mitral Regurgitation in a Canine Model
Background Atrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms in this population are poorly understood. This study examined the effects of acute left atrial volume overload on atrial electrophysiology an...
Saved in:
Published in | The Annals of thoracic surgery Vol. 103; no. 4; pp. 1277 - 1284 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Inc
01.04.2017
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background Atrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms in this population are poorly understood. This study examined the effects of acute left atrial volume overload on atrial electrophysiology and the inducibility of AF. Methods Ten canines underwent insertion of an atrioventricular shunt between the left ventricle and left atrium. Shunt and aortic flows were calculated, and the shunt was titrated to a shunt fraction to 40% to 50% of cardiac output. An epicardial plaque with 250 bipolar electrodes was used to determine activation and refractory periods. Biatrial pressures and volumes, conduction times, and atrial fibrillation inducibility were recorded. Data were collected at baseline and 20 minutes after shunt opening and closure. Results Mean shunt flow was 1.3 ± 0.5 L/min with a shunt fraction of 43% ± 6% simulating moderate to severe mitral regurgitation. Compared with baseline, left atrial volumes and maximum pressures increased by 27% and 29%, respectively, after shunt opening. Biatrial effective refractory periods did not change significantly after shunt opening or closure. Conduction times increased by 9% with shunt opening and returned to baseline after closure. AF duration or inducibility did not change with shunt opening. Conclusions This canine model of mitral regurgitation demonstrated that acute left atrial volume overload did not increase the inducibility of atrial arrhythmias in contrast with experimental and clinical findings of chronic left atrial volume overload. This suggests that the substrates for AF in patients with mitral regurgitation are a result of chronic remodeling. |
---|---|
AbstractList | Atrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms in this population are poorly understood. This study examined the effects of acute left atrial volume overload on atrial electrophysiology and the inducibility of AF.
Ten canines underwent insertion of an atrioventricular shunt between the left ventricle and left atrium. Shunt and aortic flows were calculated, and the shunt was titrated to a shunt fraction to 40% to 50% of cardiac output. An epicardial plaque with 250 bipolar electrodes was used to determine activation and refractory periods. Biatrial pressures and volumes, conduction times, and atrial fibrillation inducibility were recorded. Data were collected at baseline and 20 minutes after shunt opening and closure.
Mean shunt flow was 1.3 ± 0.5 L/min with a shunt fraction of 43% ± 6% simulating moderate to severe mitral regurgitation. Compared with baseline, left atrial volumes and maximum pressures increased by 27% and 29%, respectively, after shunt opening. Biatrial effective refractory periods did not change significantly after shunt opening or closure. Conduction times increased by 9% with shunt opening and returned to baseline after closure. AF duration or inducibility did not change with shunt opening.
This canine model of mitral regurgitation demonstrated that acute left atrial volume overload did not increase the inducibility of atrial arrhythmias in contrast with experimental and clinical findings of chronic left atrial volume overload. This suggests that the substrates for AF in patients with mitral regurgitation are a result of chronic remodeling. BACKGROUNDAtrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms in this population are poorly understood. This study examined the effects of acute left atrial volume overload on atrial electrophysiology and the inducibility of AF.METHODSTen canines underwent insertion of an atrioventricular shunt between the left ventricle and left atrium. Shunt and aortic flows were calculated, and the shunt was titrated to a shunt fraction to 40% to 50% of cardiac output. An epicardial plaque with 250 bipolar electrodes was used to determine activation and refractory periods. Biatrial pressures and volumes, conduction times, and atrial fibrillation inducibility were recorded. Data were collected at baseline and 20 minutes after shunt opening and closure.RESULTSMean shunt flow was 1.3 ± 0.5 L/min with a shunt fraction of 43% ± 6% simulating moderate to severe mitral regurgitation. Compared with baseline, left atrial volumes and maximum pressures increased by 27% and 29%, respectively, after shunt opening. Biatrial effective refractory periods did not change significantly after shunt opening or closure. Conduction times increased by 9% with shunt opening and returned to baseline after closure. AF duration or inducibility did not change with shunt opening.CONCLUSIONSThis canine model of mitral regurgitation demonstrated that acute left atrial volume overload did not increase the inducibility of atrial arrhythmias in contrast with experimental and clinical findings of chronic left atrial volume overload. This suggests that the substrates for AF in patients with mitral regurgitation are a result of chronic remodeling. Background Atrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms in this population are poorly understood. This study examined the effects of acute left atrial volume overload on atrial electrophysiology and the inducibility of AF. Methods Ten canines underwent insertion of an atrioventricular shunt between the left ventricle and left atrium. Shunt and aortic flows were calculated, and the shunt was titrated to a shunt fraction to 40% to 50% of cardiac output. An epicardial plaque with 250 bipolar electrodes was used to determine activation and refractory periods. Biatrial pressures and volumes, conduction times, and atrial fibrillation inducibility were recorded. Data were collected at baseline and 20 minutes after shunt opening and closure. Results Mean shunt flow was 1.3 ± 0.5 L/min with a shunt fraction of 43% ± 6% simulating moderate to severe mitral regurgitation. Compared with baseline, left atrial volumes and maximum pressures increased by 27% and 29%, respectively, after shunt opening. Biatrial effective refractory periods did not change significantly after shunt opening or closure. Conduction times increased by 9% with shunt opening and returned to baseline after closure. AF duration or inducibility did not change with shunt opening. Conclusions This canine model of mitral regurgitation demonstrated that acute left atrial volume overload did not increase the inducibility of atrial arrhythmias in contrast with experimental and clinical findings of chronic left atrial volume overload. This suggests that the substrates for AF in patients with mitral regurgitation are a result of chronic remodeling. |
Author | Zhang, Andrew J., BA Kopek, Michael A., MD Damiano, Ralph J., MD Miller, Jacob R., MD Lawrance, Christopher P., MD Schuessler, Richard B., PhD Henn, Matthew C., MD |
AuthorAffiliation | 2 Division of Cardiothoracic Anesthesia, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO 1 Division of Cardiothoracic Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO |
AuthorAffiliation_xml | – name: 2 Division of Cardiothoracic Anesthesia, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO – name: 1 Division of Cardiothoracic Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO |
Author_xml | – sequence: 1 fullname: Lawrance, Christopher P., MD – sequence: 2 fullname: Henn, Matthew C., MD – sequence: 3 fullname: Miller, Jacob R., MD – sequence: 4 fullname: Kopek, Michael A., MD – sequence: 5 fullname: Zhang, Andrew J., BA – sequence: 6 fullname: Schuessler, Richard B., PhD – sequence: 7 fullname: Damiano, Ralph J., MD |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27756468$$D View this record in MEDLINE/PubMed |
BookMark | eNqNUk1vEzEQtVARTQt_AfnIZbf-3PVeKpUoQKUCEpSz5XhnEwfHDvZupfx7vEopHydOlt-8eTN6by7QWYgBEMKU1JTQ5mpXm3Ebk7F5SjUrSE1UTSh9hhZUSlY1THZnaEEI4ZXoWnmOLnLelS8r5RfonLWtbESjFujT_RbwyoMdUzxsj9lFHzfO4tUwFCzjOOAbO42AP7oxGY-_wGZKGzea0cWAXcAGL01woRBiD_4lej4Yn-HV43uJvr1b3S8_VHef398ub-4qK7kYq0bxBoQwzA5KEGo5F3INjVlbJltoiVTcsJZ0XAhhB0IK1Fnet1YOg1wLzi_R9Un3MK330FsI83b6kNzepKOOxum_K8Ft9SY-6OIOp2wWePMokOKPCfKo9y5b8N4EiFPWVHEpOqEYLVR1otoUc04wPI2hRM9x6J3-HYee49BE6RJHaX3955pPjb_8L4S3JwIUsx4cJJ2tg2Chd6n4r_vo_mfK9T8i1rvgrPHf4Qh5F6cUShia6sw00V_ns5ivgjackkYx_hOT6bhI |
CitedBy_id | crossref_primary_10_1016_j_jtcvs_2019_08_059 crossref_primary_10_1016_j_jtcvs_2018_05_078 |
Cites_doi | 10.1016/S0008-6363(96)00054-5 10.1161/01.STR.22.8.983 10.1111/j.1540-8167.2005.00297.x 10.1016/j.jtcvs.2010.08.067 10.1007/s003950170045 10.1161/01.CIR.0000066915.15187.51 10.1161/01.CIR.96.6.1863 10.1161/01.RES.5.5.539 10.1161/01.CIR.96.5.1686 10.1161/01.CIR.96.10.3710 10.1111/j.1540-8167.1996.tb00596.x 10.1016/j.echo.2005.10.005 10.1016/j.hrthm.2012.10.041 10.1093/oxfordjournals.eurheartj.a060433 10.1016/S0022-5223(19)40322-X 10.1016/j.athoracsur.2007.10.097 |
ContentType | Journal Article |
Copyright | The Society of Thoracic Surgeons 2017 The Society of Thoracic Surgeons Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: The Society of Thoracic Surgeons – notice: 2017 The Society of Thoracic Surgeons – notice: Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
DOI | 10.1016/j.athoracsur.2016.08.011 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1552-6259 |
EndPage | 1284 |
ExternalDocumentID | 10_1016_j_athoracsur_2016_08_011 27756468 S0003497516310682 1_s2_0_S0003497516310682 |
Genre | Journal Article |
GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R01 HL032257 – fundername: NHLBI NIH HHS grantid: T32 HL007776 |
GroupedDBID | - 08R 0R 1- 1B1 1P 1~5 23M 3O- 4.4 457 4G. 53G 55 5GY 5RE 5VS 6J9 7-5 71M AAEDT AAEJM AAIAV AALRI AAQFI AAQQT AAQXK AAXUO ABFLS ABLJU ABMAC ABOCM ABWYI ACGFO ACGFS ACIUM ACRZS ADACO ADBBV ADPAM AENEX AEVXI AFCTW AFFNX AFRHN AFTJW AGHFR AGZHU AI. AITUG AJJEV AJUYK ALMA_UNASSIGNED_HOLDINGS ALXNB AMRAJ ASPBG AVWKF AZFZN BAWUL BELOY C5W CS3 DIK E3Z EBS EFJIC EJD F5P FDB FEDTE FGOYB FO GBLVA GJ GX1 HVGLF HZ IH2 IHE IPNFZ J1W J5H K K-O KOM L7B M41 MO0 N9A NQ- O9- OA- OK1 OL. OVD P2P P6G PC. R2- RIG ROL RPZ SES SSZ TEORI TR2 UDS UNMZH UV1 VH1 W8F X7M XH2 XPP Z5R ZA5 ZGI ZXP --- --K .1- .55 .FO .GJ 0R~ 1P~ AAEDW ABJNI ADMUD AHPSJ HZ~ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c534t-6836e44a2cf8401c3345be6abc257e70583a27093444cf00e709c3d7c5ff5b433 |
ISSN | 0003-4975 |
IngestDate | Tue Sep 17 21:14:00 EDT 2024 Fri Aug 16 21:05:25 EDT 2024 Fri Aug 23 00:46:16 EDT 2024 Sat Sep 28 08:47:35 EDT 2024 Fri Feb 23 02:30:27 EST 2024 Thu Aug 18 17:13:49 EDT 2022 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Language | English |
License | Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c534t-6836e44a2cf8401c3345be6abc257e70583a27093444cf00e709c3d7c5ff5b433 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | http://www.annalsthoracicsurgery.org/article/S0003497516310682/pdf |
PMID | 27756468 |
PQID | 1835494821 |
PQPubID | 23479 |
PageCount | 8 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5523123 proquest_miscellaneous_1835494821 crossref_primary_10_1016_j_athoracsur_2016_08_011 pubmed_primary_27756468 elsevier_sciencedirect_doi_10_1016_j_athoracsur_2016_08_011 elsevier_clinicalkeyesjournals_1_s2_0_S0003497516310682 |
PublicationCentury | 2000 |
PublicationDate | 2017-04-01 |
PublicationDateYYYYMMDD | 2017-04-01 |
PublicationDate_xml | – month: 04 year: 2017 text: 2017-04-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | The Annals of thoracic surgery |
PublicationTitleAlternate | Ann Thorac Surg |
PublicationYear | 2017 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Beeri, Yosefy, Guerrero (bib13) 2007; 116 Vasan, Larson, Levy, Evans, Benjamin (bib2) 1997; 96 Ravelli, Allessie (bib7) 1997; 96 Sideris, Toumanidis, Thodorakis (bib9) 1994; 15 Wijffels, Kirchhof, Dorland, Power, Allessie (bib11) 1997; 96 Elvan, Adiyaman, Beukema, Sie, Allessie (bib18) 2013; 10 Wolf, Abbott, Kannel (bib1) 1991; 22 Nazir, Lab (bib5) 1996; 32 (bib16) 2011 Huang, Tai, Lin (bib8) 2006; 17 Verheule, Wilson, Everett, Shanbhag, Golden, Olgin (bib12) 2003; 107 Satoh, Zipes (bib10) 1996; 7 Braunwald, Welch, Sarnoff (bib14) 1957; 5 Damiano, Schwartz, Bailey (bib3) 2011; 141 Gammie, Haddad, Milford-Beland (bib4) 2008; 85 Rankin, Nicholas, Kouchoukos (bib15) 1975; 70 Lang, Bierig, Devereux (bib17) 2005; 18 Eckardt, Kirchhof, Breithardt, Haverkamp (bib6) 2001; 96 9315565 - Circulation. 1997 Sep 2;96(5):1686-95 18291169 - Ann Thorac Surg. 2008 Mar;85(3):909-14 7835375 - Eur Heart J. 1994 Nov;15(11):1585-9 16376782 - J Am Soc Echocardiogr. 2005 Dec;18(12 ):1440-63 17846319 - Circulation. 2007 Sep 11;116(11 Suppl):I288-93 1165639 - J Thorac Cardiovasc Surg. 1975 Sep;70(3):478-88 16533256 - J Cardiovasc Electrophysiol. 2006 Feb;17(2):178-88 21168019 - J Thorac Cardiovasc Surg. 2011 Jan;141(1):113-21 13461289 - Circ Res. 1957 Sep;5(5):539-45 23128018 - Heart Rhythm. 2013 Mar;10(3):322-30 11518193 - Basic Res Cardiol. 2001 Jul;96(4):369-80 8884512 - J Cardiovasc Electrophysiol. 1996 Sep;7(9):833-42 8776403 - Cardiovasc Res. 1996 Jul;32(1):52-61 9323074 - Circulation. 1997 Sep 16;96(6):1863-73 12732604 - Circulation. 2003 May 27;107(20):2615-22 9396475 - Circulation. 1997 Nov 18;96(10):3710-20 1866765 - Stroke. 1991 Aug;22(8):983-8 Vasan (10.1016/j.athoracsur.2016.08.011_bib2) 1997; 96 Nazir (10.1016/j.athoracsur.2016.08.011_bib5) 1996; 32 Satoh (10.1016/j.athoracsur.2016.08.011_bib10) 1996; 7 Elvan (10.1016/j.athoracsur.2016.08.011_bib18) 2013; 10 Ravelli (10.1016/j.athoracsur.2016.08.011_bib7) 1997; 96 Huang (10.1016/j.athoracsur.2016.08.011_bib8) 2006; 17 (10.1016/j.athoracsur.2016.08.011_bib16) 2011 Braunwald (10.1016/j.athoracsur.2016.08.011_bib14) 1957; 5 Eckardt (10.1016/j.athoracsur.2016.08.011_bib6) 2001; 96 Beeri (10.1016/j.athoracsur.2016.08.011_bib13) 2007; 116 Sideris (10.1016/j.athoracsur.2016.08.011_bib9) 1994; 15 Lang (10.1016/j.athoracsur.2016.08.011_bib17) 2005; 18 Wijffels (10.1016/j.athoracsur.2016.08.011_bib11) 1997; 96 Damiano (10.1016/j.athoracsur.2016.08.011_bib3) 2011; 141 Wolf (10.1016/j.athoracsur.2016.08.011_bib1) 1991; 22 Verheule (10.1016/j.athoracsur.2016.08.011_bib12) 2003; 107 Rankin (10.1016/j.athoracsur.2016.08.011_bib15) 1975; 70 Gammie (10.1016/j.athoracsur.2016.08.011_bib4) 2008; 85 |
References_xml | – volume: 107 start-page: 2615 year: 2003 end-page: 2622 ident: bib12 article-title: Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation publication-title: Circulation contributor: fullname: Olgin – volume: 17 start-page: 178 year: 2006 end-page: 188 ident: bib8 article-title: The mechanisms of an increased dominant frequency in the left atrial posterior wall during atrial fibrillation in acute atrial dilatation publication-title: J Cardiovasc Electrophysiol contributor: fullname: Lin – volume: 96 start-page: 1863 year: 1997 end-page: 1873 ident: bib2 article-title: Distribution and categorization of echocardiographic measurements in relation to reference limits: the Framingham Heart Study: formulation of a height- and sex-specific classification and its prospective validation publication-title: Circulation contributor: fullname: Benjamin – volume: 96 start-page: 3710 year: 1997 end-page: 3720 ident: bib11 article-title: Electrical remodeling due to atrial fibrillation in chronically instrumented conscious goats: roles of neurohumoral changes, ischemia, atrial stretch, and high rate of electrical activation publication-title: Circulation contributor: fullname: Allessie – volume: 7 start-page: 833 year: 1996 end-page: 842 ident: bib10 article-title: Unequal atrial stretch in dogs increases dispersion of refractoriness conducive to developing atrial fibrillation publication-title: J Cardiovasc Electrophysiol contributor: fullname: Zipes – volume: 10 start-page: 322 year: 2013 end-page: 330 ident: bib18 article-title: Electrophysiological effects of acute atrial stretch on persistent atrial fibrillation in patients undergoing open heart surgery publication-title: Heart Rhythm contributor: fullname: Allessie – volume: 22 start-page: 983 year: 1991 end-page: 988 ident: bib1 article-title: Atrial fibrillation as an independent risk factor for stroke: the Framingham Study publication-title: Stroke contributor: fullname: Kannel – year: 2011 ident: bib16 article-title: Guide for the care and use of laboratory animals – volume: 15 start-page: 1585 year: 1994 end-page: 1589 ident: bib9 article-title: Some observations on the mechanism of pressure related atrial fibrillation publication-title: Eur Heart J contributor: fullname: Thodorakis – volume: 116 start-page: I288 year: 2007 end-page: I293 ident: bib13 article-title: Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study publication-title: Circulation contributor: fullname: Guerrero – volume: 96 start-page: 1686 year: 1997 end-page: 1695 ident: bib7 article-title: Effects of atrial dilatation on refractory period and vulnerability to atrial fibrillation in the isolated Langendorff-perfused rabbit heart publication-title: Circulation contributor: fullname: Allessie – volume: 70 start-page: 478 year: 1975 end-page: 488 ident: bib15 article-title: Experimental mitral regurgitation: effects on left ventricular function before and after elimination of chronic regurgitation in the dog publication-title: J Thorac Cardiovasc Surg contributor: fullname: Kouchoukos – volume: 141 start-page: 113 year: 2011 end-page: 121 ident: bib3 article-title: The Cox maze IV procedure: predictors of late recurrence publication-title: J Thorac Cardiovasc Surg contributor: fullname: Bailey – volume: 18 start-page: 1440 year: 2005 end-page: 1463 ident: bib17 article-title: Chamber Quantification Writing Group; American Society of Echocardiography's Guidelines and Standards Committee; European Association of Echocardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology publication-title: J Am Soc Echocardiogr contributor: fullname: Devereux – volume: 96 start-page: 369 year: 2001 end-page: 380 ident: bib6 article-title: Load-induced changes in repolarization: evidence from experimental and clinical data publication-title: Basic Res Cardiol contributor: fullname: Haverkamp – volume: 5 start-page: 539 year: 1957 end-page: 545 ident: bib14 article-title: Hemodynamic effects of quantitatively varied experimental mitral regurgitation publication-title: Circ Res contributor: fullname: Sarnoff – volume: 85 start-page: 909 year: 2008 end-page: 914 ident: bib4 article-title: Atrial fibrillation correction surgery: lessons from The Society of Thoracic Surgeons National Cardiac Database publication-title: Ann Thorac Surg contributor: fullname: Milford-Beland – volume: 32 start-page: 52 year: 1996 end-page: 61 ident: bib5 article-title: Mechanoelectric feedback and atrial arrhythmias publication-title: Cardiovasc Res contributor: fullname: Lab – volume: 32 start-page: 52 year: 1996 ident: 10.1016/j.athoracsur.2016.08.011_bib5 article-title: Mechanoelectric feedback and atrial arrhythmias publication-title: Cardiovasc Res doi: 10.1016/S0008-6363(96)00054-5 contributor: fullname: Nazir – volume: 22 start-page: 983 year: 1991 ident: 10.1016/j.athoracsur.2016.08.011_bib1 article-title: Atrial fibrillation as an independent risk factor for stroke: the Framingham Study publication-title: Stroke doi: 10.1161/01.STR.22.8.983 contributor: fullname: Wolf – volume: 17 start-page: 178 year: 2006 ident: 10.1016/j.athoracsur.2016.08.011_bib8 article-title: The mechanisms of an increased dominant frequency in the left atrial posterior wall during atrial fibrillation in acute atrial dilatation publication-title: J Cardiovasc Electrophysiol doi: 10.1111/j.1540-8167.2005.00297.x contributor: fullname: Huang – volume: 141 start-page: 113 year: 2011 ident: 10.1016/j.athoracsur.2016.08.011_bib3 article-title: The Cox maze IV procedure: predictors of late recurrence publication-title: J Thorac Cardiovasc Surg doi: 10.1016/j.jtcvs.2010.08.067 contributor: fullname: Damiano – volume: 96 start-page: 369 year: 2001 ident: 10.1016/j.athoracsur.2016.08.011_bib6 article-title: Load-induced changes in repolarization: evidence from experimental and clinical data publication-title: Basic Res Cardiol doi: 10.1007/s003950170045 contributor: fullname: Eckardt – volume: 107 start-page: 2615 year: 2003 ident: 10.1016/j.athoracsur.2016.08.011_bib12 article-title: Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation publication-title: Circulation doi: 10.1161/01.CIR.0000066915.15187.51 contributor: fullname: Verheule – volume: 96 start-page: 1863 year: 1997 ident: 10.1016/j.athoracsur.2016.08.011_bib2 article-title: Distribution and categorization of echocardiographic measurements in relation to reference limits: the Framingham Heart Study: formulation of a height- and sex-specific classification and its prospective validation publication-title: Circulation doi: 10.1161/01.CIR.96.6.1863 contributor: fullname: Vasan – volume: 116 start-page: I288 issue: 11 Suppl year: 2007 ident: 10.1016/j.athoracsur.2016.08.011_bib13 article-title: Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study publication-title: Circulation contributor: fullname: Beeri – volume: 5 start-page: 539 year: 1957 ident: 10.1016/j.athoracsur.2016.08.011_bib14 article-title: Hemodynamic effects of quantitatively varied experimental mitral regurgitation publication-title: Circ Res doi: 10.1161/01.RES.5.5.539 contributor: fullname: Braunwald – volume: 96 start-page: 1686 year: 1997 ident: 10.1016/j.athoracsur.2016.08.011_bib7 article-title: Effects of atrial dilatation on refractory period and vulnerability to atrial fibrillation in the isolated Langendorff-perfused rabbit heart publication-title: Circulation doi: 10.1161/01.CIR.96.5.1686 contributor: fullname: Ravelli – volume: 96 start-page: 3710 year: 1997 ident: 10.1016/j.athoracsur.2016.08.011_bib11 article-title: Electrical remodeling due to atrial fibrillation in chronically instrumented conscious goats: roles of neurohumoral changes, ischemia, atrial stretch, and high rate of electrical activation publication-title: Circulation doi: 10.1161/01.CIR.96.10.3710 contributor: fullname: Wijffels – year: 2011 ident: 10.1016/j.athoracsur.2016.08.011_bib16 – volume: 7 start-page: 833 year: 1996 ident: 10.1016/j.athoracsur.2016.08.011_bib10 article-title: Unequal atrial stretch in dogs increases dispersion of refractoriness conducive to developing atrial fibrillation publication-title: J Cardiovasc Electrophysiol doi: 10.1111/j.1540-8167.1996.tb00596.x contributor: fullname: Satoh – volume: 18 start-page: 1440 year: 2005 ident: 10.1016/j.athoracsur.2016.08.011_bib17 publication-title: J Am Soc Echocardiogr doi: 10.1016/j.echo.2005.10.005 contributor: fullname: Lang – volume: 10 start-page: 322 year: 2013 ident: 10.1016/j.athoracsur.2016.08.011_bib18 article-title: Electrophysiological effects of acute atrial stretch on persistent atrial fibrillation in patients undergoing open heart surgery publication-title: Heart Rhythm doi: 10.1016/j.hrthm.2012.10.041 contributor: fullname: Elvan – volume: 15 start-page: 1585 year: 1994 ident: 10.1016/j.athoracsur.2016.08.011_bib9 article-title: Some observations on the mechanism of pressure related atrial fibrillation publication-title: Eur Heart J doi: 10.1093/oxfordjournals.eurheartj.a060433 contributor: fullname: Sideris – volume: 70 start-page: 478 year: 1975 ident: 10.1016/j.athoracsur.2016.08.011_bib15 article-title: Experimental mitral regurgitation: effects on left ventricular function before and after elimination of chronic regurgitation in the dog publication-title: J Thorac Cardiovasc Surg doi: 10.1016/S0022-5223(19)40322-X contributor: fullname: Rankin – volume: 85 start-page: 909 year: 2008 ident: 10.1016/j.athoracsur.2016.08.011_bib4 article-title: Atrial fibrillation correction surgery: lessons from The Society of Thoracic Surgeons National Cardiac Database publication-title: Ann Thorac Surg doi: 10.1016/j.athoracsur.2007.10.097 contributor: fullname: Gammie |
SSID | ssj0002155 |
Score | 2.2819862 |
Snippet | Background Atrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms... Atrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms in this... BACKGROUNDAtrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms... |
SourceID | pubmedcentral proquest crossref pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 1277 |
SubjectTerms | Acute Disease Animals Atrial Fibrillation - diagnosis Atrial Fibrillation - etiology Atrial Fibrillation - physiopathology Atrial Pressure Cardiothoracic Surgery Disease Models, Animal Dogs Heart Conduction System - physiopathology Mitral Valve Insufficiency - complications Mitral Valve Insufficiency - physiopathology Surgery |
Title | The Electrophysiologic Effects of Acute Mitral Regurgitation in a Canine Model |
URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0003497516310682 https://dx.doi.org/10.1016/j.athoracsur.2016.08.011 https://www.ncbi.nlm.nih.gov/pubmed/27756468 https://search.proquest.com/docview/1835494821 https://pubmed.ncbi.nlm.nih.gov/PMC5523123 |
Volume | 103 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBahe9nL2Ngtu6HB3oyDrZtt9hRCttLRMrYW8iZsRW7TDqc0DoP9j_3fHV18SzrW9UUkkiNbOp-Pjk4-nYPQB56UBRdah0zzEgqShRlVNBRRmSwFGOjckmiOT8ThGTta8MVo9LvHWtrWxUT9uvVcyX2kCnUgV3NK9j8k23YKFfAZ5AslSBjKO8t47vLYWA-FU2TBvONoTJXhARyvjD8DpvJ8e3Pug3IbR0cezPLKmJkmI9qPvp1qczW3sZXrCwCKgp43vUPUNlrjT5OXQ-9EKQi-TjoXq7OPfVrxYNa2dIcQj0ApF8G3tuXL-lpf9Sj9wXTS903AetdRWhp9S00OOz7QtxHtAYv1tGdMfEoX7b-67HF7Wt45HC5hsu3wYeyGoydsLFavugeBtXcWvJaG2DDcLmXXkzQ9SZOa05wYf0CSjBum6OdFxxwCK4k3iRjN4DxBzNEGb3-mv1k9-7uaXXJuz9o5fYwe-W0KnjrMPUEjXT1FJ4AKvI837PGG1yW2eMMOb3iAN7yqcI4d3rDF2zN09ml-OjsMfT6OUHHK6lCkVGjGcqLKFLblilLGCy3yQoHe10nEU5qTJMooY0yVUQRVmaLLRPGy5AWj9Dk6qNaVfolwAQt0odNsCYYTK8AkWiYxJbC3jdQyhikdo7iZL3ntwq7If0lrjJJmYmVzrBgWQr3xb-xGxnJDZCS_u6hMCYe9SByJlIzRx_aX3vB0BqUExN3hvu8bKUrQzeYPt7zS6y3cz3hVM5YSuOaFk2o7GoA6F0yk8NQDebcXmLjvw5ZqdWHjv3MOmzJCX91jjl6jh917-gYd1Ddb_Ras6rp4ZzH-B5_2zsg |
link.rule.ids | 230,315,786,790,891,27955,27956 |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Electrophysiologic+Effects+of+Acute+Mitral+Regurgitation+in+a+Canine+Model&rft.jtitle=The+Annals+of+thoracic+surgery&rft.au=Lawrance%2C+Christopher+P.&rft.au=Henn%2C+Matthew+C.&rft.au=Miller%2C+Jacob+R.&rft.au=Kopek%2C+Michael+A.&rft.date=2017-04-01&rft.issn=0003-4975&rft.volume=103&rft.issue=4&rft.spage=1277&rft.epage=1284&rft_id=info:doi/10.1016%2Fj.athoracsur.2016.08.011&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_athoracsur_2016_08_011 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-4975&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-4975&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-4975&client=summon |