Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2)

• Published in: Autophagy Vol. 14; no. 4; pp. 671 - 684
• Main Authors: Jiao, Lin, Zhang, Hai-Liang, Li, Dan-Dan, Yang, Ke-Li, Tang, Jun, Li, Xuan, Ji, Jiao, Yu, Yan, Wu, Rui-Yan, Ravichandran, Senthilkumar, Liu, Jian-Jun, Feng, Gong-Kan, Chen, Min-Shan, Zeng, Yi-Xin, Deng, Rong, Zhu, Xiao-Feng
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.04.2018
• Subjects: autophagy; glycolysis; hexokinase 2; liver cancer; Research Papers - Basic Science; SQSTM1/p62; TRAF6; ubiquitination; SQSTM1/p62; autophagy; hexokinase 2; ubiquitination; TRAF6; glycolysis; liver cancer

Impaired macroautophagy/autophagy and high levels of glycolysis are prevalent in liver cancer. However, it remains unknown whether there is a regulatory relationship between autophagy and glycolytic metabolism. In this study, by utilizing cancer cells with basal or impaired autophagic flux, we demon...