Therapeutic potential of CERE-110 (AAV2-NGF): Targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons - Bishop, Kathie M.; Hofer, Eva K.; Mehta, Arpesh; Ramirez, Anthony; Sun, Liangwu; Tuszynski, Mark; Bartus, Raymond T. (Experimental neurology, 2008)
Keywords: Adeno-associated virus; Adenoviridae - genetics; Adenoviridae - metabolism; Adult and adolescent clinical studies; Alzheimer's disease; Animals; Basal forebrain cholinergic neurons; Biological and medical sciences; CERE-110; Cholinergic Fibers - metabolism; Cholinergic Fibers - virology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Development. Senescence. Regeneration. Transplantation; Dose–response; Drug Delivery Systems - methods; Fundamental and applied biological sciences. Psychology; Gene delivery; Genetic Vectors - administration & dosage; Genetic Vectors - metabolism; Humans; Male; Marmota; Medical sciences; Nerve Degeneration - drug therapy; Nerve Degeneration - genetics; Nerve Degeneration - prevention & control; Nerve growth factor; Nerve Growth Factor - administration & dosage; Nerve Growth Factor - metabolism; Nerve Growth Factor - therapeutic use; Neurology; Neurotrophin; Nucleus basalis of Meynert; Organic mental disorders. Neuropsychology; Prosencephalon - cytology; Prosencephalon - metabolism; Prosencephalon - virology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Trophic activity; Vertebrates: nervous system and sense organs; Neurotrophin; Nucleus basalis of Meynert; Gene delivery; Adeno-associated virus; Dose–response; CERE-110; Trophic activity; Nerve growth factor; Basal forebrain cholinergic neurons; Alzheimer's disease; Cholinergic neuron; Nervous system diseases; Growth; Alzheimer disease; Rodentia; Cerebral disorder; Vertebrata; Mammalia; Treatment; Animal; Central nervous system disease; Degenerative disease; Adeno-associated virus; Alzheimer's disease; Basal forebrain cholinergic neurons; CERE-110; Dose-response; Gene delivery; Nerve growth factor; Neurotrophin; Nucleus basalis of Meynert; Trophic activity