Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism

Interventions to the gut microbiome manipulate the gut-brain axis and could be useful in the treatment of anxiety and depression. In this study, we demonstrated that administration of the bacterium reduces anxiety-like behavior in adult zebrafish. administration increased the diversity of the zebraf...

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Published inFrontiers in microbiology Vol. 14; p. 1079187
Main Authors Ichikawa, Shunsuke, Abe, Reimi, Fujimoto, Haruka, Higashi, Koushi, Zang, Liqing, Nakayama, Hiroko, Matsuoka, Izumi, Shimada, Yasuhito
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.02.2023
Subjects
Burkholderiaceae
Danio rerio
mental diseases
Microbiology
novel tank diving
stress
stress
Burkholderiaceae
novel tank diving
mental diseases
Danio rerio
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Summary:Interventions to the gut microbiome manipulate the gut-brain axis and could be useful in the treatment of anxiety and depression. In this study, we demonstrated that administration of the bacterium reduces anxiety-like behavior in adult zebrafish. administration increased the diversity of the zebrafish gut microbiome. Linear discriminant analysis Effect Size (LEfSe) analysis revealed that the populations of Actinomycetales including Nocardiaceae, , Gordoniaceae, , Nakamurellaceae, and Aeromonadaceae were reduced, whereas those of Rhizobiales including Xanthobacteraceae, Bradyrhizobiaceae, Rhodospirillaceae, and Pirellulaceae were increased in the gut microbiome. Functional analysis using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt2) predicted that administration altered taurine metabolism in the zebrafish gut, and we demonstrated that administration increased the taurine concentration in the brain. Since taurine functions as an antidepressant neurotransmitter in vertebrates, our results suggest that could improve anxiety-like behavior in zebrafish the gut-brain axis.
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Edited by: Reeta Goel, GLA University, India
This article was submitted to Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology
Reviewed by: Kiran Veer Sandhu, University College Cork, Ireland; Aurelijus Burokas, Vilnius University, Lithuania
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2023.1079187