Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma

• Published in: Journal of allergy and clinical immunology Vol. 141; no. 4; pp. 1231 - 1238.e1
• Main Authors: Burbank, Allison J., Duran, Charity G., Pan, Yinghao, Burns, Patricia, Jones, Susan, Jiang, Qing, Yang, Chao, Jenkins, Sha’Leema, Wells, Heather, Alexis, Neil, Kesimer, Mehmet, Bennett, William D., Zhou, Haibo, Peden, David B., Hernandez, Michelle L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018; Elsevier Limited
• Subjects: Adult; Animal models; Antioxidants; Asthma; Asthma - drug therapy; Asthma - immunology; Asthma - metabolism; Biomarkers - metabolism; Blood diseases; Chronic illnesses; Clinical trials; Cross-Over Studies; Cytokines; Double-Blind Method; Drug Administration Schedule; Drug dosages; endotoxin; Endotoxins - administration & dosage; Endotoxins - adverse effects; Endotoxins - immunology; eosinophil; Eosinophilia; Eosinophilia - drug therapy; Eosinophilia - metabolism; Eosinophils - drug effects; Eosinophils - metabolism; Family medical history; Female; gamma-Tocopherol - pharmacology; gamma-Tocopherol - therapeutic use; Granulocytes; Humans; Hypotheses; Inflammation; Leukocytes (eosinophilic); Leukocytes (neutrophilic); lipopolysaccharide; Lipopolysaccharides; Male; Middle Aged; Mucin; Mucins - metabolism; mucociliary clearance; neutrophil; Neutrophil Infiltration - drug effects; Neutrophilia; Neutrophils; Respiratory tract; Respiratory tract diseases; Rodents; Scintigraphy; Sputum; Sputum - drug effects; Sputum - metabolism; Supplements; tocopherol; Treatment Outcome; Vitamin E; Vitamins - pharmacology; Vitamins - therapeutic use; γ-CEHC; γT; αT; vitamin E; PMNs; tocopherol; MCC; neutrophil; MUC5AC; Asthma; mucin; mucociliary clearance; eosinophil; lipopolysaccharide; endotoxin

We and others have shown that the gamma tocopherol (γT) isoform of vitamin E has multiple anti-inflammatory and antioxidant actions and that γT supplementation reduces eosinophilic and endotoxin (LPS)-induced neutrophilic airway inflammation in animal models and healthy human volunteers. We sought t...