Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma - Burbank, Allison J.; Duran, Charity G.; Pan, Yinghao; Burns, Patricia; Jones, Susan; Jiang, Qing; Yang, Chao; Jenkins, Sha’Leema; Wells, Heather; Alexis, Neil; Kesimer, Mehmet; Bennett, William D.; et al. (Journal of allergy and clinical immunology, 2018)
Keywords: Adult; Animal models; Antioxidants; Asthma; Asthma - drug therapy; Asthma - immunology; Asthma - metabolism; Biomarkers - metabolism; Blood diseases; Chronic illnesses; Clinical trials; Cross-Over Studies; Cytokines; Double-Blind Method; Drug Administration Schedule; Drug dosages; endotoxin; Endotoxins - administration & dosage; Endotoxins - adverse effects; Endotoxins - immunology; eosinophil; Eosinophilia; Eosinophilia - drug therapy; Eosinophilia - metabolism; Eosinophils - drug effects; Eosinophils - metabolism; Family medical history; Female; gamma-Tocopherol - pharmacology; gamma-Tocopherol - therapeutic use; Granulocytes; Humans; Hypotheses; Inflammation; Leukocytes (eosinophilic); Leukocytes (neutrophilic); lipopolysaccharide; Lipopolysaccharides; Male; Middle Aged; Mucin; Mucins - metabolism; mucociliary clearance; neutrophil; Neutrophil Infiltration - drug effects; Neutrophilia; Neutrophils; Respiratory tract; Respiratory tract diseases; Rodents; Scintigraphy; Sputum; Sputum - drug effects; Sputum - metabolism; Supplements; tocopherol; Treatment Outcome; Vitamin E; Vitamins - pharmacology; Vitamins - therapeutic use; γ-CEHC; γT; αT; vitamin E; PMNs; tocopherol; MCC; neutrophil; MUC5AC; Asthma; mucin; mucociliary clearance; eosinophil; lipopolysaccharide; endotoxin