Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity

• Published in: Gut microbes Vol. 13; no. 1; p. 1946368
• Main Authors: Cruz-Lebrón, Angélica, Johnson, Ramona, Mazahery, Claire, Troyer, Zach, Joussef-Piña, Samira, Quiñones-Mateu, Miguel E., Strauch, Christopher M, Hazen, Stanley L., Levine, Alan D.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2021; Taylor & Francis Group
• Subjects: Adult; Akkermansia muciniphila; Analgesics, Opioid - adverse effects; Analgesics, Opioid - therapeutic use; Animals; Dysbiosis - chemically induced; Dysbiosis - physiopathology; Female; Gastrointestinal Microbiome - drug effects; Healthy Volunteers; Humans; Intestinal permeability; Male; metabolomics; methadone; Methadone - therapeutic use; Middle Aged; Opioid-Related Disorders - drug therapy; Opioid-Related Disorders - epidemiology; Opioid-Related Disorders - physiopathology; Research Paper; short-chain fatty acids; tight junctions; United States; United States; Akkermansia muciniphila; tight junctions; short-chain fatty acids; metabolomics; methadone; Intestinal permeability

Over the past three decades the United States has experienced a devastating opioid epidemic. One of the many debilitating side effects of chronic opioid use is opioid-induced bowel dysfunction. We investigated the impact of methadone maintenance treatment (MMT) on the gut microbiome, the gut bacteri...