Case report: Common clonal origin of concurrent langerhans cell histiocytosis and acute myeloid leukemia

• Published in: Frontiers in Oncology Vol. 12; p. 974307
• Main Authors: Kazama, Shintaro, Yokoyama, Kazuaki, Ueki, Toshimitsu, Kazumoto, Hiroko, Satomi, Hidetoshi, Sumi, Masahiko, Ito, Ichiro, Yusa, Nozomi, Kasajima, Rika, Shimizu, Eigo, Yamaguchi, Rui, Imoto, Seiya, Miyano, Satoru, Tanaka, Yukihisa, Denda, Tamami, Ota, Yasunori, Tojo, Arinobu, Kobayashi, Hikaru
• Format: Journal Article
• Language: English
• Published: Frontiers Media SA 16.09.2022; Frontiers Media S.A
• Subjects: acute myeloid leukemia; dendritic cells; histiocytic disorders; langerhans cell histiocytosis; MAPK pathway; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; NRAS; Oncology; RC254-282

Langerhans cell histiocytosis (LCH) and acute myeloid leukemia (AML) are distinct entities of blood neoplasms, and the exact developmental origin of both neoplasms are considered be heterogenous among patients. However, reports of concurrent LCH and AML are rare. Herein we report a novel case of con...