Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

• Published in: JCI insight Vol. 6; no. 14
• Main Authors: Martino, Nina, Ramos, Ramon Bossardi, Lu, Shuhan, Leyden, Kara, Tomaszek, Lindsay, Sadhu, Sudeshna, Fredman, Gabrielle, Jaitovich, Ariel, Vincent, Peter A, Adam, Alejandro P
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 22.07.2021; American Society for Clinical investigation
• Subjects: Animals; Disease Models, Animal; Endothelium, Vascular - pathology; Endotoxemia - diagnosis; Endotoxemia - immunology; Endotoxemia - mortality; Endotoxemia - pathology; Heterozygote; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Interleukin-6 - metabolism; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - immunology; Mice; Mice, Knockout; Proteolysis; Severity of Illness Index; Suppressor of Cytokine Signaling 3 Protein - analysis; Suppressor of Cytokine Signaling 3 Protein - genetics; Suppressor of Cytokine Signaling 3 Protein - metabolism; Ubiquitination; Vascular biology; Signal transduction; Inflammation; Cytokines; Vascular Biology; Endothelial cells

SOCS3 is the main inhibitor of the JAK/STAT3 pathway. This pathway is activated by interleukin 6 (IL-6), a major mediator of the cytokine storm during shock. To determine its role in the vascular response to shock, we challenged mice lacking SOCS3 in the adult endothelium (SOCS3iEKO) with a nonletha...