Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer’s disease

• Published in: Alzheimer's research & therapy Vol. 14; no. 1; pp. 166 - 12
• Main Authors: Biel, Davina, Luan, Ying, Brendel, Matthias, Hager, Paul, Dewenter, Anna, Moscoso, Alexis, Otero Svaldi, Diana, Higgins, Ixavier A., Pontecorvo, Michael, Römer, Sebastian, Steward, Anna, Rubinski, Anna, Zheng, Lukai, Schöll, Michael, Shcherbinin, Sergey, Ewers, Michael, Franzmeier, Nicolai
• Format: Journal Article
• Language: English
• Published: England BioMed Central 07.11.2022; BMC
• Subjects: Accuracy; Age; Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer's disease; Amyloid - metabolism; Amyloid beta-Peptides - metabolism; association workgroups; Brain; Brain - diagnostic imaging; Brain - metabolism; Clinical trials; Cognitive ability; Cognitive decline; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - psychology; criteria; Dementia; diagnostic guidelines; fMRI; functional connectivity; Humans; impairment; Magnetic Resonance Imaging - methods; Medical imaging; medicine; Memory; national institute; Neurodegeneration; Neuroimaging; Neurosciences; Neurosciences & Neurology; Neurovetenskaper; Pathology; Patient-Centered Care; Patients; Positron-Emission Tomography - methods; Precision; Precision medicine; recommendations; tau Proteins - metabolism; Tau-PET; trials; Working groups; Cognitive decline; fMRI; Alzheimer’s disease; Precision medicine; Tau-PET

Tau-PET is a prognostic marker for cognitive decline in Alzheimer's disease, and the heterogeneity of tau-PET patterns matches cognitive symptom heterogeneity. Thus, tau-PET may allow precision-medicine prediction of individual tau-related cognitive trajectories, which can be important for dete...