Prevalence and natural history of variants in the ANKRD26 gene: a short review and update of reported cases

ANKRD26 is a highly conserved gene located on chromosome 10p12.1 which has shown to play a role in normal megakaryocyte differentiation. ANKRD26-related thrombocytopenia, or thrombocytopenia 2, is an inherited thrombocytopenia with mild bleeding diathesis resulting from point mutations the 5ʹUTR of...

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Published inPlatelets (Edinburgh) Vol. 33; no. 8; pp. 1107 - 1112
Main Authors Vyas, Hrushikesh, Alcheikh, Ahmad, Lowe, Gillian, Stevenson, William S, Morgan, Neil V, Rabbolini, David J
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 17.11.2022
Taylor & Francis Group
Subjects
5' Untranslated Regions
ANKRD26
Collection
Genetic Predisposition to Disease
Humans
inherited thrombocytopenia AML
Intercellular Signaling Peptides and Proteins - genetics
MDS
Mutation
platelet disorder
Prevalence
thrombocytopenia
Thrombocytopenia - genetics
Thrombocytopenia - pathology
Transcription Factors - genetics
platelet disorder
ANKRD26
inherited thrombocytopenia AML
thrombocytopenia
MDS
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Abstract ANKRD26 is a highly conserved gene located on chromosome 10p12.1 which has shown to play a role in normal megakaryocyte differentiation. ANKRD26-related thrombocytopenia, or thrombocytopenia 2, is an inherited thrombocytopenia with mild bleeding diathesis resulting from point mutations the 5ʹUTR of the ANKRD26 gene. Point mutations in the 5ʹUTR region have been shown to prevent transcription factor-mediated downregulation of ANKRD26 in normal megakaryocyte differentiation. Patients with ANKRD26-related thrombocytopenia have a predisposition to developing hematological malignancies, with acute myeloid leukemia and myelodysplastic syndrome most commonly described in the literature. We review the clinical features and biological mechanisms of ANKRD26-related thrombocytopenia and summarize known cases in the literature.
AbstractList ANKRD26 is a highly conserved gene located on chromosome 10p12.1 which has shown to play a role in normal megakaryocyte differentiation. ANKRD26-related thrombocytopenia, or thrombocytopenia 2, is an inherited thrombocytopenia with mild bleeding diathesis resulting from point mutations the 5ʹUTR of the ANKRD26 gene. Point mutations in the 5ʹUTR region have been shown to prevent transcription factor-mediated downregulation of ANKRD26 in normal megakaryocyte differentiation. Patients with ANKRD26-related thrombocytopenia have a predisposition to developing hematological malignancies, with acute myeloid leukemia and myelodysplastic syndrome most commonly described in the literature. We review the clinical features and biological mechanisms of ANKRD26-related thrombocytopenia and summarize known cases in the literature.
is a highly conserved gene located on chromosome 10p12.1 which has shown to play a role in normal megakaryocyte differentiation. -related thrombocytopenia, or thrombocytopenia 2, is an inherited thrombocytopenia with mild bleeding diathesis resulting from point mutations the 5'UTR of the gene. Point mutations in the 5'UTR region have been shown to prevent transcription factor-mediated downregulation of in normal megakaryocyte differentiation. Patients with -related thrombocytopenia have a predisposition to developing hematological malignancies, with acute myeloid leukemia and myelodysplastic syndrome most commonly described in the literature. We review the clinical features and biological mechanisms of -related thrombocytopenia and summarize known cases in the literature.
ANKRD26 is a highly conserved gene located on chromosome 10p12.1 which has shown to play a role in normal megakaryocyte differentiation. ANKRD26 -related thrombocytopenia, or thrombocytopenia 2, is an inherited thrombocytopenia with mild bleeding diathesis resulting from point mutations the 5ʹUTR of the ANKRD26 gene. Point mutations in the 5ʹUTR region have been shown to prevent transcription factor-mediated downregulation of ANKRD26 in normal megakaryocyte differentiation. Patients with ANKRD26 -related thrombocytopenia have a predisposition to developing hematological malignancies, with acute myeloid leukemia and myelodysplastic syndrome most commonly described in the literature. We review the clinical features and biological mechanisms of ANKRD26 -related thrombocytopenia and summarize known cases in the literature.
Author Vyas, Hrushikesh
Alcheikh, Ahmad
Lowe, Gillian
Stevenson, William S
Morgan, Neil V
Rabbolini, David J
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Cites_doi 10.1080/09537104.2020.1854544
10.1182/blood.2019852418
10.1182/blood-2013-03-489344
10.3389/fgene.2020.00340
10.1080/09537104.2017.1280151
10.1182/blood-2011-02-336537
10.1002/pbc.25668
10.3389/fcvm.2019.00080
10.1007/s00431-015-2549-x
10.1002/ajh.26321
10.1111/jth.13850
10.1016/j.scr.2020.102002
10.1007/s12185-017-2259-4
10.1111/jth.13855
10.1038/s41467-020-16042-w
10.1084/jem.20210444
10.15252/embj.2020104844
10.1160/TH12-07-0497
10.3109/10428194.2014.903476
10.1172/JCI71861
10.1007/s00108-013-3284-x
10.1093/dnares/6.3.197
10.1093/nar/gkaa1100
10.1016/j.ajhg.2010.12.006
10.1182/blood-2017-02-735290
10.1038/srep43526
10.1111/cge.12603
10.1016/j.thromres.2017.01.001
10.1155/2019/9357572
10.1007/s00429-014-0741-9
10.3389/fcell.2017.00111
10.1177/2324709620938941
10.1038/nrm4062
10.1080/09537104.2016.1267337
10.3390/ijms22094521
10.1038/modpathol.2016.218
10.1111/bjh.16543
10.1182/blood-2013-04-499319
10.1002/jcla.23896
10.1016/j.blre.2020.100784
10.1007/s00277-019-03632-y
10.1186/s13045-016-0382-y
10.1038/bcj.2015.41
10.1016/j.gene.2005.07.045
10.1093/annonc/mdw066
10.1073/pnas.0710978105
10.1111/ijlh.12999
10.1016/j.hemonc.2021.01.002
10.1086/302637
10.1038/nature13302
10.15252/embj.2020105106
10.1186/s13148-019-0768-0
10.1073/pnas.0608344103
10.1046/j.1365-2141.2001.03068.x
10.1080/23723556.2021.1893625
10.3109/09537104.2015.1129225
10.1038/s41467-018-08216-4
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Keywords platelet disorder
ANKRD26
inherited thrombocytopenia AML
thrombocytopenia
MDS
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cit0029
cit0026
cit0024
cit0025
cit0011
cit0055
cit0012
cit0056
cit0053
cit0010
cit0054
cit0051
cit0052
cit0050
cit0019
cit0017
cit0018
cit0015
cit0059
cit0016
cit0013
cit0057
cit0014
cit0058
cit0044
cit0001
Lazaro E (cit0027) 2019; 31
cit0045
cit0042
cit0043
cit0040
cit0041
Botero JP (cit0007) 2018
cit0008
cit0009
cit0006
cit0004
cit0048
cit0005
cit0049
cit0002
cit0046
cit0003
cit0047
References_xml – ident: cit0019
  doi: 10.1080/09537104.2020.1854544
– ident: cit0001
  doi: 10.1182/blood.2019852418
– ident: cit0014
  doi: 10.1182/blood-2013-03-489344
– ident: cit0050
  doi: 10.3389/fgene.2020.00340
– ident: cit0002
  doi: 10.1080/09537104.2017.1280151
– ident: cit0011
  doi: 10.1182/blood-2011-02-336537
– ident: cit0046
  doi: 10.1002/pbc.25668
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  doi: 10.3389/fcvm.2019.00080
– ident: cit0022
  doi: 10.1007/s00431-015-2549-x
– ident: cit0006
  doi: 10.1002/ajh.26321
– ident: cit0021
  doi: 10.1111/jth.13850
– ident: cit0052
  doi: 10.1016/j.scr.2020.102002
– ident: cit0033
  doi: 10.1007/s12185-017-2259-4
– ident: cit0030
  doi: 10.1111/jth.13855
– ident: cit0039
  doi: 10.1038/s41467-020-16042-w
– ident: cit0054
  doi: 10.1084/jem.20210444
– ident: cit0058
  doi: 10.15252/embj.2020104844
– ident: cit0017
  doi: 10.1160/TH12-07-0497
– ident: cit0025
  doi: 10.3109/10428194.2014.903476
– ident: cit0042
  doi: 10.1172/JCI71861
– ident: cit0047
  doi: 10.1007/s00108-013-3284-x
– ident: cit0034
  doi: 10.1093/dnares/6.3.197
– ident: cit0036
  doi: 10.1093/nar/gkaa1100
– ident: cit0009
  doi: 10.1016/j.ajhg.2010.12.006
– ident: cit0032
  doi: 10.1182/blood-2017-02-735290
– ident: cit0043
  doi: 10.1038/srep43526
– ident: cit0028
  doi: 10.1111/cge.12603
– ident: cit0049
  doi: 10.1016/j.thromres.2017.01.001
– start-page: 1993
  volume-title: GeneReviews®
  year: 2018
  ident: cit0007
  contributor:
    fullname: Botero JP
– ident: cit0020
  doi: 10.1155/2019/9357572
– volume: 31
  start-page: 1
  issue: 6
  year: 2019
  ident: cit0027
  publication-title: Platelets
  contributor:
    fullname: Lazaro E
– ident: cit0055
  doi: 10.1007/s00429-014-0741-9
– ident: cit0031
  doi: 10.3389/fcell.2017.00111
– ident: cit0048
  doi: 10.1177/2324709620938941
– ident: cit0056
  doi: 10.1038/nrm4062
– ident: cit0024
  doi: 10.1080/09537104.2016.1267337
– ident: cit0004
  doi: 10.3390/ijms22094521
– ident: cit0018
  doi: 10.1038/modpathol.2016.218
– ident: cit0045
  doi: 10.1111/bjh.16543
– ident: cit0010
  doi: 10.1182/blood-2013-04-499319
– ident: cit0013
  doi: 10.1002/jcla.23896
– ident: cit0029
  doi: 10.1016/j.blre.2020.100784
– ident: cit0026
  doi: 10.1007/s00277-019-03632-y
– ident: cit0012
  doi: 10.1186/s13045-016-0382-y
– ident: cit0023
  doi: 10.1038/bcj.2015.41
– ident: cit0038
  doi: 10.1016/j.gene.2005.07.045
– ident: cit0051
  doi: 10.1093/annonc/mdw066
– ident: cit0040
  doi: 10.1073/pnas.0710978105
– ident: cit0005
  doi: 10.1111/ijlh.12999
– ident: cit0015
  doi: 10.1016/j.hemonc.2021.01.002
– ident: cit0008
  doi: 10.1086/302637
– ident: cit0035
  doi: 10.1038/nature13302
– ident: cit0057
  doi: 10.15252/embj.2020105106
– ident: cit0044
  doi: 10.1186/s13148-019-0768-0
– ident: cit0037
  doi: 10.1073/pnas.0608344103
– ident: cit0053
  doi: 10.1046/j.1365-2141.2001.03068.x
– ident: cit0059
  doi: 10.1080/23723556.2021.1893625
– ident: cit0016
  doi: 10.3109/09537104.2015.1129225
– ident: cit0041
  doi: 10.1038/s41467-018-08216-4
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Snippet ANKRD26 is a highly conserved gene located on chromosome 10p12.1 which has shown to play a role in normal megakaryocyte differentiation. ANKRD26-related...
is a highly conserved gene located on chromosome 10p12.1 which has shown to play a role in normal megakaryocyte differentiation. -related thrombocytopenia, or...
ANKRD26 is a highly conserved gene located on chromosome 10p12.1 which has shown to play a role in normal megakaryocyte differentiation. ANKRD26 -related...
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SubjectTerms 5' Untranslated Regions
ANKRD26
Collection
Genetic Predisposition to Disease
Humans
inherited thrombocytopenia AML
Intercellular Signaling Peptides and Proteins - genetics
MDS
Mutation
platelet disorder
Prevalence
thrombocytopenia
Thrombocytopenia - genetics
Thrombocytopenia - pathology
Transcription Factors - genetics
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Title Prevalence and natural history of variants in the ANKRD26 gene: a short review and update of reported cases
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