The mechanism of triptolide in the treatment of connective tissue disease-related interstitial lung disease based on network pharmacology and molecular docking

• Published in: Annals of medicine (Helsinki) Vol. 54; no. 1; pp. 541 - 552
• Main Authors: Zhu, Wen, Li, Yehui, Zhao, Junjie, Wang, Yifan, Li, Yixi, Wang, Yue
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 31.12.2022; Taylor & Francis Group
• Subjects: Connective Tissue Diseases; CTD-ILD; Diterpenes; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Epoxy Compounds; Humans; Lung Diseases, Interstitial - drug therapy; Molecular docking; Molecular Docking Simulation; Network Pharmacology; Phenanthrenes; Phosphatidylinositol 3-Kinases; Pulmonary Medicine; Tripterygium wilfordii; Triptolide; Network pharmacology; CTD-ILD; Tripterygium wilfordii; Triptolide; Molecular docking

Interstitial lung disease (ILD) is associated with substantial morbidity and mortality, which is one of the key systematic manifestations of connective tissue disease (CTD). Tripterygium wilfordii, known as Leigongteng in Chinese, has been applied to treat connective tissue disease-related interstit...