Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ)

• Published in: Frontiers in immunology Vol. 13; p. 1034880
• Main Authors: Dankers, Wendy, Northcott, Melissa, Bennett, Taylah, D'Cruz, Akshay, Sherlock, Rochelle, Gearing, Linden J, Hertzog, Paul, Russ, Brendan, Miceli, Iolanda, Scheer, Sebastian, Fujishiro, Maki, Hayakawa, Kunihiro, Ikeda, Keigo, Morand, Eric F, Jones, Sarah A
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.11.2022
• Subjects: GILZ; glucocorticoid; Glucocorticoids - pharmacology; Humans; Immunology; inflammation; interferon; Interferon Type I; Janus Kinase Inhibitors; Janus Kinases; Leucine Zippers; Leukocytes, Mononuclear; Quality of Life; Signal Transduction; STAT Transcription Factors; STAT1; systemic lupus erythematosus (SLE); GILZ; glucocorticoid; systemic lupus erythematosus (SLE); autoimmunity; STAT1; inflammation; interferon

SLE is a systemic multi-organ autoimmune condition associated with reduced life expectancy and quality of life. Glucocorticoids (GC) are heavily relied on for SLE treatment but are associated with detrimental metabolic effects. Type 1 interferons (IFN) are central to SLE pathogenesis and may confer...